Publicaciones 2021

  1. Leonardo A. Pérez, Aysha Rashid, J. Dale Combs, Pascal Schneider, Andrés Rodríguez, Khalid Salaita and Lisette Leyton. An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes. Front. Cell Dev. Biol.,9:2241, 23 August 2021. Descargar
  2. Zárate, A.M., Espinosa-Bustos, C., Guerrero, S., Fierro, A., Oyarzún-Ampuero, F., Quest, A.F.G., Di Marcotullio, L., Loricchio, E., Caimano, M., Calcaterra, A., González-Quiroz, M., Aguirre, A., Meléndez, J., Salas, C.O. “A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo”. Int J Mol Sci. 2021 Aug 4;22(16):8372.Link
  3. Burgos-Ravanal, R., Campos, A., Díaz-Vesga, M.C., González, M.F., León, D., Lobos-González, L., Leyton, L., Kogan, M.J., Quest, A.F.G. “Extracellular Vesicles as Mediators of Cancer Disease and as Nanosystems in Theranostic Applications”. Cancers (Basel). 2021 Jul 2;13(13):3324. Link 
  4. González, M.F., Díaz, P., Sandoval-Bórquez, A., Herrera, D., Quest, A.F.G. “Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development”. Int J Mol Sci. 2021 May 1;22(9):4823.Link
  5. Díaz, P., Sandoval-Bórquez, A., Bravo-Sagua, R., Quest, A.F.G., Lavandero, S. “Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease”. Front Cell Dev Biol. 2021 Feb 25;9:613336. Link
  6. Brenet, M., Martínez, S., Pérez-Nuñez, R., Pérez, L.A., Contreras, P., Díaz, J., Avalos, A.M., Schneider, P., Quest, A.F.G. and Leyton, L. “Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca2+/P2X7 Receptor Signaling Axis”. Front. Cell Dev. Biol. 2021 Jan 12;8:592442. Link
  7. Díaz, P., Román, A., Carrasco-Aviño, G., Rodríguez, A., Corvalán, A.H., Lavandero, S. and Quest, A.F.G. “Helicobacter Pylori Infection Triggers PERK-Associated Survivin Loss in Gastric Tissue Samples and Cell Lines”. J Cancer Sci Clin Ther 2021; 5 (1): 063-082. Link
  8. Troncoso MF, Pavez M, Wilson C, Lagos D, Duran J, Ramos S, Barrientos G, Silva P, Llanos P, Basualto-Alarcón C, Westenbrink BD, Lavandero S, Estrada M. «Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy». Biol Res. 2021 Feb 5;54(1):3.Link
  9. Schiattarella GG, Altamirano F, Kim SY, Tong D, Ferdous A, Piristine H, Dasgupta S, Wang X, French KM, Villalobos E, Spurgin SB, Waldman M, Jiang N, May HI, Hill TM, Luo Y, Yoo H, Zaha VG, Lavandero S, Gillette TG, Hill JA. «Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction». Nat Commun. 2021 Mar 16;12(1):1684.Link
  10. Luo Y, Jiang N, May HI, Luo X, Ferdous A, Schiattarella GG, Chen G, Li Q, Li C, Rothermel BA, Jiang D, Lavandero S, Gillette TG, Hill JA. «Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy». Circulation. 2021 Jul 6;144(1):34-51. Link
  11. Buvinic S, Balanta-Melo J, Kupczik K, Vásquez W, Beato C, Toro-Ibacache V. «Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions». Front Endocrinol (Lausanne). 2021 Mar 1;11:606947. Link
  12. Jaque-Fernández F, Jorquera G, Troc-Gajardo J, Pietri-Rouxel F, Gentil C, Buvinic S, Allard B, Jaimovich E, Jacquemond V, Casas M. «Pannexin-1 and CaV1.1 show reciprocal interaction during excitation-contraction and excitation-transcription coupling in skeletal muscle». J Gen Physiol. 2021 Dec 6;153(12):e202012635. Link
  13. Herrera-Zelada N, Zuñiga-Cuevas U, Ramirez-Reyes A, Lavandero S, Riquelme JA. Targeting the Endothelium to Achieve Cardioprotection. Front Pharmacol. 2021 Feb 2;12:636134.Link
  14. Ramírez-Sagredo A, Quiroga C, Garrido-Moreno V, López-Crisosto C, Leiva-Navarrete S, Norambuena-Soto I, Ortiz-Quintero J, Díaz-Vesga MC, Perez W, Hendrickson T, Parra V, Pedrozo Z, Altamirano F, Chiong M, Lavandero S. Polycystin-1 regulates cardiomyocyte mitophagy. FASEB J. 2021 Aug;35(8):e21796.Link
  15. Troncoso MF, Ortiz-Quintero J, Garrido-Moreno V, Sanhueza-Olivares F, Guerrero-Moncayo A, Chiong M, Castro PF, García L, Gabrielli L, Corbalán R, Garrido-Olivares L, Lavandero S. VCAM-1 as a predictor biomarker in cardiovascular disease. Biochim Biophys Acta Mol Basis Dis. 2021 Sep 1;1867(9):166170.Link
  16. Américo-Da-Silva L, Aguilera J, Quinteros-Waltemath O, Sánchez-Aguilera P, Russell J, Cadagan C, Meneses-Valdés R, Sánchez G, Estrada M, Jorquera G, Barrientos G, Llanos P. Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance. Int J Mol Sci. 2021 Sep 23;22(19):10212.Link
  17. Villar-Fincheira P, Sanhueza-Olivares F, Norambuena-Soto I, Cancino-Arenas N, Hernandez-Vargas F, Troncoso R, Gabrielli L, Chiong M. Role of Interleukin-6 in Vascular Health and Disease. Front Mol Biosci. 2021 Mar 16;8:641734.Link
  18. Gatica D, Chiong M, Lavandero S, Klionsky DJ. The role of autophagy in cardiovascular pathology. Cardiovasc Res. 2021 May 6:cvab158.Link
  19. Palacios J, Benites J, Owen GI, Morales P, Chiong M, Nwokocha CR, Paredes A, Cifuentes F. Impact of the Potential Antitumor Agent 2-(4-Hydroxyphenyl) Amino-1,4-Naphthoquinone (Q7) on Vasomotion Is Mediated by the Vascular Endothelium, But Not Vascular Smooth Muscle Cell Metabolism. J Cardiovasc Pharmacol. 2021 Feb 1;77(2):245-252.Link
  20. Villar-Fincheira P, Paredes AJ, Hernández-Díaz T, Norambuena-Soto I, Cancino-Arenas N, Sanhueza-Olivares F, Contreras-Briceño F, Mandiola J, Bruneau N, García L, Ocaranza MP, Troncoso R, Gabrielli L, Chiong M. Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners. Front Physiol. 2021 Oct 11;12:722528.Link
  21. Fernández C, Torrealba N, Altamirano F, Garrido-Moreno V, Vásquez-Trincado C, Flores-Vergara R, López-Crisosto C, Ocaranza MP, Chiong M, Pedrozo Z, Lavandero S. Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy. PLoS One. 2021 Aug 18;16(8):e0255452.Link
  22. Contreras-Briceño F, Herrera S, Vega-Adauy J, Salinas M, Ocaranza MP, Jalil JE, Mandiola J, García L, Chiong M, Castro PF, Lavandero S, Gabrielli L. Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners. Front Cardiovasc Med. 2021 Nov 1;8:737285.Link
  23. Contreras-Briceño F, Vega J, Mandiola J, Ocaranza MP, Herrera S, Salinas M, Fernández R, Jalil JE, Lavandero S, Chiong M, Godoy P, Castro PF, Sitges M, Gabrielli L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J Cardiovasc Dev Dis. 2021 Sep 24;8(10):118.Link
  24. Vivero A, Ruz M, Rivera M, Miranda K, Sacristán C, Espinosa A, Codoceo J, Inostroza J, Vásquez K, Pérez Á, García-Díaz D, Arredondo M. Zinc Supplementation and Strength Exercise in Rats with Type 2 Diabetes: Akt and PTP1B Phosphorylation in Nonalcoholic Fatty Liver. Biol Trace Elem Res. 2021 Jun;199(6):2215-2224.Link
  25. Morales PE, Monsalves-Álvarez M, Tadinada SM, Harris MP, Ramírez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Lavandero S. Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. FASEB J. 2021 Oct;35(10):e21933.Link
  26. Dovale-Rosabal G, Rodríguez A, Espinosa A, Barriga A, Aubourg SP. Synthesis of EPA- and DHA-Enriched Structured Acylglycerols at the sn-2 Position Starting from Commercial Salmon Oil by Enzymatic Lipase Catalysis under Supercritical Conditions. Molecules. 2021 May 22;26(11):3094.Link
  27. Lopez-Crisosto C, Arias-Carrasco R, Sepulveda P, Garrido-Olivares L, Maracaja-Coutinho V, Verdejo HE, Castro PF, Lavandero S. Novel molecular insights and public omics data in pulmonary hypertension. Biochim Biophys Acta Mol Basis Dis. 2021 Oct 1;1867(10):166200.Link
  28. Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA. NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction. Circ Res. 2021 May 28;128(11):1629-1641.Link
  29. Lopez-Crisosto C, Díaz-Vegas A, Castro PF, Rothermel BA, Bravo-Sagua R, Lavandero S. Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells. Cell Death Dis. 2021 Jun 28;12(7):657.Link
  30. Olivares-Silva F, De Gregorio N, Espitia-Corredor J, Espinoza C, Vivar R, Silva D, Osorio JM, Lavandero S, Peiró C, Sánchez-Ferrer C, Díaz-Araya G. Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166241.Link
  31. Ayala P, Montenegro J, Vivar R, Letelier A, Aránguiz Urroz P, Copaja M, Pivet D, Humeres C, Troncoso R, Vicencio JM, Lavandero S, Díaz-Araya G. Corrigendum to «Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol» [Experimental and Molecular Pathology Volume 92, Issue 1, February 2012, Pages 97-104]. Exp Mol Pathol. 2021 Aug;121:104669.Link
  32. Mosqueira M, Brinkmeier H, Jaimovich E. Editorial: Calcium Homeostasis in Skeletal Muscle Function, Plasticity, and Disease. Front Physiol. 2021 Mar 26;12:671292.Link
  33. Quezada ER, Díaz-Vegas A, Jaimovich E, Casas M. Changes in Gene Expression of the MCU Complex Are Induced by Electrical Stimulation in Adult Skeletal Muscle. Front Physiol. 2021 Jan 26;11:601313.Link
  34. Jorquera G, Meneses-Valdés R, Rosales-Soto G, Valladares-Ide D, Campos C, Silva-Monasterio M, Llanos P, Cruz G, Jaimovich E, Casas M. High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice. Diabetologia. 2021 Jun;64(6):1389-1401.Link
  35. Basualto-Alarcón C, Llanos P, García-Rivas G, Troncoso MF, Lagos D, Barrientos G, Estrada M. Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men. Int J Endocrinol. 2021 Jul 21;2021:5527973.Link
  36. Jorquera G, Russell J, Monsalves-Álvarez M, Cruz G, Valladares-Ide D, Basualto-Alarcón C, Barrientos G, Estrada M, Llanos P. NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle. Int J Mol Sci. 2021 Mar 23;22(6):3254.Link
  37. Torres MJ, López-Moncada F, Herrera D, Indo S, Lefian A, Llanos P, Tapia J, Castellón EA, Contreras HR. Endothelin-1 induces changes in the expression levels of steroidogenic enzymes and increases androgen receptor and testosterone production in the PC3 prostate cancer cell line. Oncol Rep. 2021 Aug;46(2):171.Link
  38. Sepúlveda-Rivas S, Leal MS, Pedrozo Z, Kogan MJ, Ocaranza MP, Morales JO. Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy. Pharmaceutics. 2021 Jun 1;13(6):822.Link
  39. Sanhueza S, Tobar N, Cifuentes M, Quenti D, Varì R, Scazzocchio B, Masella R, Herrera K, Paredes A, Morales G, Ormazabal P. Lampaya Medicinalis Phil. decreases lipid-induced triglyceride accumulation and proinflammatory markers in human hepatocytes and fat body of Drosophila melanogaster. Int J Obes (Lond). 2021 Jul;45(7):1464-1475.Link
  40. Catalán M, Rodríguez C, Olmedo I, Carrasco-Rojas J, Rojas D, Molina-Berríos A, Díaz-Dosque M, Jara JA. Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin. Adv Exp Med Biol. 2021;1326:95-109.Link
  41. Arauna D, Navarrete S, Devia M, Rodríguez L, Reyes L, Wehinger S, Silva-Weiss A, Palomo I, Fuentes E. The Role of Coffee and its Bioactive Components in Platelet Function and Aging. Mini Rev Med Chem. 2021 Apr 5.Link
  42. Lizama PM, Ríos DL, Cachinero IS, Lopez-Egea AT, Camps A, Belzares O, Pacheco C, Cerro C, Wehinger S, Fuentes E, Marrugat J, Palomo I. Association of Kidney Disease, Potassium, and Cardiovascular Risk Factor Prevalence with Coronary Arteriosclerotic Burden, by Sex. J Pers Med. 2021 Jul 27;11(8):722.Link
  43. Palacios J, Benites J, Owen GI, Morales P, Chiong M, Nwokocha CR, Paredes A, Cifuentes F. Impact of the Potential Antitumor Agent 2-(4-Hydroxyphenyl) Amino-1,4-Naphthoquinone (Q7) on Vasomotion Is Mediated by the Vascular Endothelium, But Not Vascular Smooth Muscle Cell Metabolism. J Cardiovasc Pharmacol. 2021 Feb 1;77(2):245-252.Link
  44. Orellana-Serradell O, Díaz MC, González MF, Gutiérrez M, Herrera D, Jara D, Maureira D, Ruiz-Fuentes JL, Sanhueza S, Leyton L. Does Peer Reviewing for COVID-19-Related Papers Still Work? Front Res Metr Anal. 2020 Oct 8;5:571886.Link
  45. Contreras-Briceño F, Herrera S, Vega-Adauy J, Salinas M, Ocaranza MP, Jalil JE, Mandiola J, García L, Chiong M, Castro PF, Lavandero S, Gabrielli L. Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners. Front Cardiovasc Med. 2021 Nov 1;8:737285.Link
  46. Contreras-Briceño F, Vega J, Mandiola J, Ocaranza MP, Herrera S, Salinas M, Fernández R, Jalil JE, Lavandero S, Chiong M, Godoy P, Castro PF, Sitges M, Gabrielli L. Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners. J Cardiovasc Dev Dis. 2021 Sep 24;8(10):118.Link
  47. Morales PE, Monsalves-Álvarez M, Tadinada SM, Harris MP, Ramírez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Lavandero S. Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. FASEB J. 2021 Oct;35(10):e21933.Link
  48. Buvinic S, Balanta-Melo J, Kupczik K, Vásquez W, Beato C, Toro-Ibacache V. Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions. Front Endocrinol (Lausanne). 2021 Mar 1;11:606947.Link