Publicaciones 2018

  1. Del Campo A, Contreras-Hernández I, Castro-Sepúlveda M, Campos CA, Figueroa R, Tevy MF, Eisner V, Casas M, Jaimovich E. Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice. Aging (Albany NY), Vol. 10, No. 1, 2018
  2. Jaimovich E, Casas M. Evaluating the essential role of RONS in vivo in exercised human muscle. Acta Physiol (Oxf). 222, e 12972. 2018
  3. Jamileth Y. More, Barbara A. Bruna, Pedro E. Lobos, Jose´ L. Galaz, Paula L. Figueroa, Silvia Namias, Gina L. Sanchez, Genaro C. Barrientos, Jose´ L. Valdes, Andrea C. Paula-Lima, Cecilia Hidalgo, and Tatiana Adasme, Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory ANTIOXIDANTS & REDOX SIGNALING Volume 29, Number 12, 2018
  4. Inostroza-Riquelme, M., Vivanco, A., Lara, P, Guerrero, S., Salas, E, Chamorro A, Leyton L, Bolaños K, Araya E, Quest A.F.G, Kogan M, Oyarzun-Ampuero F, Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential Molecules, 23(5), 1208, 2018
  5. Peña-Oyarzun D, Bravo-Sagua R, Diaz A, Aleman L, Chiong M, Garcia L, Bambs C, Troncoso R, Cifuentes M, Morselli E, Ferreccio C, Quest AFG, Criollo A, Lavandero S. Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?, Free Rad Biol Med , 124,61-78,2018
  6. Guerrero S, Diaz V, Contreras P, Lara P, Palma S, Guzman F, Lobos L, Cardenas A, Rojas X, Leyton L, Kogan MJ, Quest AFG, Gold nanoparticles as tracking devices to shed light on the role of Caveolin-1 in early stages of melanoma metastasis, Nanomedicine, 12(13), 1447-1462, 2018
  7. Diaz P, Valenzuela-Valderama M, Bravo J, Quest AFG, Helicobacter pylori and gastric cancer: Adaptive cellular mechanisms involved in disease progression. Frontiers in Microbiology, 22, 43229, 2018
  8. Garrido M, Vera C, Vega M, Quest AFG, Romero C, Metformin prevents NGF-dependent proliferative and pro-angiogenic effects in epithelial ovarian cancer cells and endothelial cells. Therapeutic Advances in Medical Oncology, Vol. 10: 1 –16 2018
  9. Cerda-Opazo P, Valenzuela-Valderrama M, Wichmann I, Rodríguez A, Contreras D, Fernández E, Carrasco G, Corvalán AH, Quest AFG, Inverse correlation between Survivin and Reprimo predicts poorer survival rates in gastric cancer. Oncotarget, 9 (16), 12853-12867, 2018
  10. Sepúlveda D, Barrera MJ, Castro I, Aguilera S, Carvajal P, Lagos C, González S, Albornoz N, BahamondesV, Quest AFG, Urzúa U, Molina C, Leyton C, Hermoso M and González MJ, Impaired IRE1/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren’s syndrome patients .Rheumatology, 57(6), 1021-1032, 2018
  11. Burgos-Bravo F, Figueroa N, Casanova N, Quest AFG, Wilson CAM, Leyton L, Single-molecule force spectroscopy measurement of Thy-1/avb3-integrin interaction using non-purified proteins. Mol. Biol. Cell, 29(3), 326-338, 2018
  12. Gabrielli L, Sitges M, Chiong M, Jalil J, Ocaranza M, Llevaneras S, Herrera S, Fernandez R, Saavedra R, Yañez F, Vergara L, Diaz A, Lavandero S, Castro P. Potential adverse cardiac remodelling in highly trained athletes: still unknown clinical significance. Eur J Sport Sci. 12,1-10,2018
  13. García-Miguel M, Riquelme JA, Norambuena-Soto I, Morales PE, Sanhueza-Olivares F, Nuñez-Soto C, Mondaca-Ruff D, Cancino-Arenas N, San Martín A, Chiong M, Autophagy mediates tumor necrosis factor-α-induced phenotype switching in vascular smooth muscle A7r5 cell line. PLoS One,13(5), May 11, 2018
  14. Navarro-Marquez M, Torrealba N, Troncoso R, Vásquez-Trincado C, Rodriguez M, Morales PE, Villalobos E, Eura Y, Garcia L, Chiong M, Klip A, Jaimovich E, Kokame K, Lavandero S. Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis. Biochim Biophys Acta. 1864, 1653-1662, 2018
  15. Shaikh S, Troncoso R, Mondaca-Ruff D, Parra V, Garcia L, Chiong M, Lavandero S. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content. Toxicol In Vitro, 48,121-127, 2018
  16. D’Espessailles A, Mora YA, Fuentes C, Cifuentes M. Calcium-sensing receptor activatesthe NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling. J Cell Physiol, 233(8),6232-6240,2018
  17. Bejarano J, Navarro-Marquez M, Morales-Zavala F, Morales JO, Garcia-Carvajal I, Araya-Fuentes E, Flores Y, Verdejo HE, Castro PF, Lavandero S, Kogan MJ, Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches.Theranostics, Vol. 8, 4710-4732 Issue 17, 2018
  18. Kitsis RN. Riquelme JA, Lavandero S. Heart disease and cancer – are the two killers colluding? Circulation, Vol 138, N°7, Pag 692–695, 2018
  19. Criollo A, Altamirano F, Pedrozo Z, Schiattarella GG, Li DL, Rivera-Mejías P, Sotomayor-Flores C, Parra V, Villalobos E, Battiprolu PK, Jiang N, May HI, Morselli E, Somlo S, de Smedt H, Gillette TG, Lavandero S, Hill JA, Polycystin-2-dependent control of cardiomyocyte autophagy. Journal of Molecular and Cellular Cardiology, 118,110-121, 2018
  20. Parra VM, Altamirano F, Hernández-Fuentes CP, Tong D, Kyrychenko V, Rotter D, Pedrozo Z, Hill JA, Eisner V, Lavandero S, Schneider JW, Rothermel BA. Down syndrome critical region 1 gene, rcan1, helps maintain a more fused mitochondrial network. Circulation Research.122, e20-e33, 2018
  21. Bernal-Sore I, Navarro-Marquez M, Osorio-Fuentealba C, Díaz-Castro F, del Campo A, Donoso-Barraza C, Porras O, Lavandero S, Troncoso R, Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells. 461, e20-e33, 2018
  22. Davidson SM, Riquelme JA, Takov K, Vicencio JM, Boi-Doku C, Khoo V, Doreth C, Radenkovic D, Lavandero S, Yellon DM. Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro. Journal of Cellular and Molecular Medicine, 22,141-151, 2018
  23. Marican A, Avila-Salas F, Valdés O, Wehinger S, Villaseñor J, Fuentealba N, Arenas-Salinas M, Argandoña Y, Carrasco-Sánchez V, Durán-Lara EF. Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform. Pharmaceutics, 10(1), E30, 2018
  24. Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging. Víctor Manuel Díaz-García, Simón Guerrero, Natalia Díaz-Valdivia, Lorena Lobos-González, Marcelo Kogan, José Manuel Pérez-Donoso, Andrew FG Quest, Int J Nanomedicine.2018 Oct 16;13:6391-6412. doi: 10.2147/IJN.S165565. eCollection 2018.
  25. Pablo Sánchez-Aguilera, Alexis Diaz-Vega, Cristián Campos, Oscar Quinteros-Waltemath , Hugo Cerda-Kohler, Genaro Barrientos, Ariel Contreras-Ferrat, Paola Llanos , Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice BBA – Molecular and Cell Biology of Lipids, Pages 1469-1477 December 2018
  26. Raúl Lagos-Cabré, Marianne Brenet, Jorge Díaz , Ramón D. Pérez, Leonardo A. Pérez , Rodrigo Herrera-Molina , Andrew F. G. Quest and Lisette Leyton , Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration International Journal of Molecular Sciencies Sci, Aug 19, 2179 2018
  27. Roberto Bravo-Sagua, Valentina Parra, Carolina Ortiz-Sandoval, Mario Navarro-Marquez, Andrea E. Rodríguez, Natalia Diaz-Valdivia, Carlos Sanhueza, Camila Lopez-Crisosto, Nasser Tahbaz, Beverly A. Rothermel, Joseph A. Hill, Mariana Cifuentes, Thomas Simmen, Andrew F. G. Quest, Sergio Lavandero, Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress Cell Death & Differentiation 10 January 2018 / Revised: 26 August 2018 / Accepted: 27 August 2018
  28. Alexis R. Díaz-Vegas, Alex Cordova, Denisse Valladares, Paola Llanos , Cecilia Hidalgo, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Rosario Rizzuto, Ariel Contreras-Ferrat and Enrique Jaimovich, Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism, 10.3389/fphys.2018.00791
  29. Julián Balanta-Melo, Viviana Toro-Ibacache, Maria Angélica Torres-Quintana ,Kornelius Kupczik, Carolina Vega, Camilo Morales, Nadia Hernández-Moya, Manuel Arias-Calderón, Carolina Beato, Sonja Buvinic, Early molecular response and microanatomical changes in themasseter muscle and mandibular head after botulinum toxinintervention in adult mice _ Annals of Anatomy, 112-119/2018.
  30. Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines.Campos A, Salomon C, Bustos R, Díaz J, Martínez S, Silva V, Reyes C, Díaz-Valdivia N, Varas-Godoy M, Lobos-González L, Quest AF. Nanomedicine (Lond). 2018 Oct. 19. doi: 10.2217/nnm-2018-0094. [Epub ahead of print
  31. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects.Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF. World J Gastroenterol. 2018 Jul 28;24(28):3071-3089. doi: 10.3748/wjg.v24.i28.3071. Review
  32. Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren’s syndrome patients.Lagos C, Carvajal P, Castro I, Jara D, González S, Aguilera S, Barrera MJ, Quest AFG, Bahamondes V, Molina C, Urzúa U, Hermoso MA, Leyton C, González MJ. Clin Immunol. 2018 Jun 9. pii: S1521-6616(18)30348-6. doi: 10.1016/j.clim.2018.06.002. [Epub ahead of print
  33. IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice.Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, Contreras-Ferrat A, Westermeier F, Jaimovich E, Marchi S, Pinton P, Lavandero S.Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3685-3695. doi: 10.1016/j.bbadis.2018.08.042. Epub 2018 Sep 7.
  34. Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse.Cerda-Kohler H, Henríquez-Olguín C, Casas M, Jensen TE, Llanos P, Jaimovich E.Physiol Rep. 2018 Sep;6(18):e13800. doi: 0.14814/phy2.13800
  35. The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K.Bruna B, Lobos P, Herrera-Molina R, Hidalgo C, Paula-Lima A, Adasme T.Biochem Biophys Res Commun. 2018 Oct. 20;505(1):201-207. doi: 10.1016/j.bbrc.2018.09.080. Epub 2018 Sep 19
  36. Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation. More J, Casas MM, Sánchez G, Hidalgo C, Haeger P.Neural Plast. 2018 Jul 5;2018:5056181. doi: 10.1155/2018/5056181. eCollection 2018.
  37. Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning.Davidson SM, Riquelme JA, Zheng Y, Vicencio JM, Lavandero S, Yellon DM.Sci Rep. 2018 Oct 26;8(1):15885. doi: 10.1038/s41598-018-34357-z.
  38. Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes. Mattar P, Bravo-Sagua R, Tobar N, Fuentes C, Troncoso R, Breitwieser G, Lavandero S, Cifuentes M. Biochim Biophys Acta Mol Basis Dis. 2018 Nov; 1864(11):3585-3594. doi: 10.1016/j.bbadis.2018.08.020. Epub 2018 Aug 18.
  39. Editorial commentary: Cardiometabolic diseases and gut microbiota-removing the veil.Riquelme JA, Ferreccio C, Lavandero S.Trends Cardiovasc Med. 2018 Sep 4. pii: S1050-1738(18)30179-8. doi: 10.1016/j.tcm.2018.08.009. [Epub ahead of print] No abstract available.
  40. Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension.Gonzalez L, Novoa U, Moya J, Gabrielli L, Jalil JE, García L, Chiong M, Lavandero S, Ocaranza MP.Biochem Pharmacol. 2018 Oct;156:357-370. doi: 10.1016/j.bcp.2018.08.045. Epub 2018 Sep 1
  41. Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT2R and Akt-dependent mechanism.Mendoza-Torres E, Riquelme JA, Vielma A, Sagredo AR, Gabrielli L, Bravo-Sagua R, Jalil JE, Rothermel BA, Sanchez G, Ocaranza MP, Lavandero S.Pharmacol Res. 2018 Sep;135:112-121. doi: 10.1016/j.phrs.2018.07.022. Epub 2018 Jul 23
  42. Increased active phase atrial contraction is related to marathon runner performance. Gabrielli L, Herrera S, Contreras-Briceño F, Vega J, Ocaranza MP, Yáñez F, Fernández R, Saavedra R, Sitges M, García L, Chiong M, Lavandero S, Castro PF.Eur J Appl Physiol. 2018 Sep;118(9):1931-1939. doi: 10.1007/s00421-018-3927-7. Epub 2018 Jul 3
  43. [Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units].Hameau R, Gabrielli L, Garrido M, Guzmán AM, Retamal I, Vacarezza MJ, Greig D, Ocqueteau M, Sánchez C, Pizarro M, Corvalán A, Lavandero S, Castro PF, Martínez G.Rev Med Chil. 2018 Jan;146(1):68-77. doi: 10.4067/s0034-98872018000100068. Review. Spanish.
  44. Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study. Palomo I, Giacaman RA, León S, Lobos G, Bustamante M, Wehinger S, Tapia JC, Fuentes M, Alarcón M, García F, Albala C, Fuentes E. Arch Gerontol Geriatr. 2018 Oct 18;80:70-75. doi: 10.1016/j.archger.2018.10.004. [Epub ahead of print]
  45. Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. Barrera C, Valenzuela R, Rincón MÁ, Espinosa A, Echeverria F, Romero N, Gonzalez-Mañan D, Videla LA. Free Radic Biol Med. 2018 Oct;126:313-321. doi: 10.1016/j.freeradbiomed.2018.08.030. Epub 2018 Aug 25.
  46. Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues. Valenzuela R, Rincón-Cervera MÁ, Echeverría F, Barrera C, Espinosa A, Hernández-Rodas MC, Ortiz M, Valenzuela A, Videla LA. Nutrition. 2018 Jan;45:49-58. doi: 10.1016/j.nut.2017.07.007. Epub 2017 Jul 17.
  47. High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice. Sánchez G, Araneda F, Peña JP, Finkelstein JP, Riquelme JA, Montecinos L, Barrientos G, Llanos P, Pedrozo Z, Said M, Bull R, Donoso P. Int J Mol Sci. 2018 Feb 10;19(2). pii: E533. doi: 10.3390/ijms19020533
  48. Autonomic imbalance in cardiac surgery: A potential determinant of the failure in remote ischemic preconditioning. Gajardo AIJ, Karachon L, Bustamante P, Repullo P, Llancaqueo M, Sánchez G, Rodrigo R. Med Hypotheses. 2018 Sep;118:146-150. doi: 10.1016/j.mehy.2018.07.002. Epub 2018 Jul 2.
  49. Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation. Campino C, Baudrand R, Valdivia CA, Carvajal C, Vecchiola A, Tapia-Castillo A, Martínez-Aguayo A, Garcia H, García L, Allende F, Solari S, Fuentes CA, Lagos CF, Rojas MP, Muñoz D, Fardella CE. Am J Hypertens. 2018 Sep 11;31(10):1127-1132. doi: 10.1093/ajh/hpy097
  50. Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction. Balanta-Melo J, Torres-Quintana MA, Bemmann M, Vega C, González C, Kupczik K, Toro-Ibacache V, Buvinic S. J Oral Rehabil. 2018 Nov 23. doi: 10.1111/joor.12747. [Epub ahead of print]
  51. Mandibular bone loss: a hidden side effect of botulinum toxin type A injection in masticatory muscles. Balanta-Melo J, Buvinic S. J Oral Res 7(2): 44-46. ISSN Online 0719-2479. Scopus
  52. N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model. More J, Galusso N, Veloso P, Montecinos L, Finkelstein JP, Sanchez G, Bull R, Valdés JL, Hidalgo C, Paula-Lima A. Front Aging Neurosci. 2018 Dec 6;10:399. doi: 10.3389/fnagi.2018.00399. eCollection 2018
  53. Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis. Guerrero S, Inostroza-Riquelme M, Contreras-Orellana P, Diaz-Garcia V, Lara P, Vivanco-Palma A, Cárdenas A, Miranda V, Robert P, Leyton L, Kogan MJ, Quest AFG, Oyarzun-Ampuero F. Nanoscale. 2018 Dec 21;10(47):22612-22622. doi: 10.1039/c8nr06173d. Epub 2018 Nov 28.
  54. Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction. Arias-Cavieres A, Barrientos GC, Sánchez G, Elgueta C, Muñoz P, Hidalgo C. Front Cell Neurosci. 2018 Nov 6;12:403. doi: 10.3389/fncel.2018.00403. eCollection 2018.
  55. Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats. Arias-Cavieres A, More J, Vicente JM, Adasme T, Hidalgo J, Valdés JL, Humeres A, Valdés-Undurraga I, Sánchez G, Hidalgo C, Barrientos G. Front Mol Neurosci. 2018 Nov 26;11:429. doi: 10.3389/fnmol.2018.00429. eCollection 2018.
  56. Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats. Cifuentes F, Palacios J, Kuzmicic J, Carvajal L, Muñoz F, Quispe C, Nwokocha CR, Morales G, Norambuena-Soto I, Chiong M, Paredes A . Phytomedicine. 2018 Nov 15;50:99-108. doi: 10.1016/j.phymed.2018.09.226. Epub 2018 Sep 26.
  57. Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells. Castillo Bennett J, Silva P, Martinez S, Torres VA, Quest AFG. Curr Mol Med. 18(4), 199-206, 2018.
  58. Díaz-García VM, Guerrero S, Díaz-Valdivia N, Lobos-González L, Kogan M, Pérez-Donoso JM, Quest AF. Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging. Int J Nanomedicine. 13; 6391-6412. 2018.
  59. D’Espessailles A, Mora YA, Fuentes C, Cifuentes. Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling.  J Cell Physiol. Aug;233(8):6232-6240. 2018.
  60. Avila-Salas F, Rodriguez Nuñez YA, Marican A, Castro RI, Villaseñor J, Santos LS, Wehinger S, Durán-Lara EF. Rational Development of a Novel Hydrogel as a pH-Sensitive Controlled Release System for Nifedipine.  Polymers (Basel). Jul 23;10(7), 2018.