Publicaciones 2017

  1. Díaz-Valdivia, N.I., Calderón, C.C., Lobos-González, L., Ortíz, R.J., Silva, V., Díaz, J.E., Maldonado, H.J., Silva, P., Wehinger, S., Burzio, V.A., Torres, V.A., Leyton, L., Quest, A.F.G. Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. Oncotarget. 8, 111943-111965. 2017.
  2. Burgos-Bravo, F., Figueroa, N.L., Casanova-Morales, N., Quest, A.F.G., Wilson, C.A.M. and Leyton, L. Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using non-purified proteins. Mol Biol Cell. [Epub ahead of print]. 2017.
  3. Maldonado, H., Calderon, C., Burgos-Bravo, F., Kobler, O., Zuschratter, W., Ramirez, O., Härtel, S., Schneider, P., Quest, A.F.G., Herrera-Molina, R., Leyton, L. Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway. Biochim Biophys Acta. 1864, 243-254. 2017.
  4. Lagos-Cabré R, Alvarez A, Kong M, Burgos-Bravo F, Cárdenas A, Rojas-Mancilla E, Pérez-Nuñez R, Herrera-Molina R, Rojas F, Schneider P, Herrera-Marschitz M, Quest AFG, van Zundert B, Leyton L. αVβ3 Integrin regulates astrocyte reactivity. J Neuroinflammation. 14, 194-2016. 2017.
  5. Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AF, Lavandero S. Calcium Transport and Signaling in Mitochondria. Compr Physiol. 7, 623-634. 2017.
  6. Lopez-Crisosto C, Pennanen C, Vasquez-Trincado C, Morales PE, Bravo-Sagua R, Quest AF, Chiong M, Lavandero S. Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology. Nat Rev Cardiol. 14, 342-360. 2017.
  7. Oyarce C, Cruz-Gomez S, Galvez-Cancino F, Vargas P, Moreau HD, Diaz-Valdivia N, Diaz J, Salazar-Onfray FA, Pacheco R, Lennon-Dumenil AM, Quest AFG, Lladser A. Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses. Front Immunol. 2017 Dec 13;8:8, 1794.2017.
  8. Canales J, Valenzuela M, Bravo J, Cerda-Opazo P, Jorquera C, Toledo H, Bravo D, Quest AF. Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells. Front Cell Infect Microbiol. 7, 92. 2017.
  9. Barrientos G, Sánchez-Aguilera P, Jaimovich E, Hidalgo C, Llanos P. Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance. J Diabetes Res. 2017.     3941898. 2017.
  10. Juretić N, Díaz J, Romero F, González G, Jaimovich E, Riveros N. Interleukin-6 and neuregulin-1 as regulators of utrophin expression via the activation of NRG-1/ErbB signaling pathway in mdx cells. Biochim Biophys Acta. 1863 770-780. 2017 .
  11. Mizgier ML, Cataldo LR, Gutierrez J, Santos JL, Casas M, Llanos P, Contreras-Ferrat AE, Moro C, Bouzakri K, Galgani JE. Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion. J Diabetes Res. 2017. 1328573. 2017.
  12. Hernández-Ochoa E, Llanos P, Lanner J. The Underlying Mechanisms of Diabetic Myopathy. J Diabetes Res. 2017. 7485738. 2017.
  13. Cataldo LR, Mizgier ML, Bravo Sagua R, Jaña F, Cárdenas C, Llanos P, Busso D, Olmos P, Galgani JE, Santos JL, Cortés VA. Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. PLoS One. 1, e0170213. 2017.
  14. Hernández-Rodas MC, Valenzuela R, Echeverría F, Rincón-Cervera MÁ, Espinosa A, Illesca P, Muñoz P, Corbari A, Romero N, Gonzalez-Mañan D, Videla LA. Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation. Mol Nutr Food Res. 61(12),  [Epub ahead of print]. 2017.
  15. Morales PE, Bucarey JL, Espinosa A. Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins. J Diabetes Res. 2017, 1789395.2017.
  16. Valenzuela R, Echeverria F, Ortiz M, Rincón-Cervera MÁ, Espinosa A, Hernandez-Rodas MC, Illesca P, Valenzuela A, Videla LA. Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice. Lipids Health Dis. 1, 64. 2017.
  17. Valenzuela R, Illesca P, Echeverría F, Espinosa A, Rincón-Cervera MÁ, Ortiz M, Hernández-Rodas MC, Valenzuela A, Videla LA. Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation. Food Funct. 4, 1526-1537. 2017.
  18. Dossi CG, Cadagan C, San Martín M, Espinosa A, González-Mañán D, Silva D, Mancilla RA, Tapia GS. Effects of rosa mosqueta oil supplementation in lipogenic markers associated with prevention of liver steatosis. Food Funct. 2, 832-841. 2017.
  19. García-Beltrán O, Mena NP, Aguirre P, Barriga-González G, Galdámez A, Nagles E, Adasme T, Hidalgo C, Núñez MT. Development of an iron-selective antioxidant probe with protective effects on neuronal function. PLoS One. 12, e0189043. 2017.
  20. Torres RF, Hidalgo C, Kerr B. Mecp2 Mediates Experience-Dependent Transcriptional Upregulation of Ryanodine Receptor Type-3. Front Mol Neurosci. 10. 188. 2017.
  21. San Martín CD, Veloso P, Adasme T, Lobos P, Bruna B, Galaz J, García A, Hartel S, Hidalgo C, Paula-Lima AC. RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers. Front Mol Neurosci. 10. 115. 2017.
  22. Arias-Cavieres A, Adasme T, Sánchez G, Muñoz P, Hidalgo C. Aging Impairs Hippocampal-Dependent Recognition Memory and LTP and Prevents the Associated RyR. Up-regulation. FrontAging Neuroscience. 9, 111. 2017.
  23. Hidalgo C. Calcium Rules Circulation. 135, 1379-1381. 2017
  24. Córdova-Casanova A, Olmedo I, Riquelme JA, Barrientos G, Sánchez G, Gillette TG, Lavandero S, Chiong M, Donoso P, Pedrozo Z. Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism. Biochim Biophys Acta. 1865. 289-296. 2017.
  25. Torrealba N, Navarro-Marquez M, Garrido V, Pedrozo Z, Romero D, Eura Y, Villalobos E, Roa JC, Chiong M, Kokame K, Lavandero S. Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation. Sci Rep. 7, 13402. 2017.
  26. Parra V, Bravo-Sagua R, Norambuena-Soto I, Hernández-Fuentes CP, Gómez-Contreras AG, Verdejo HE, Mellado R, Chiong M, Lavandero S, Castro PF. Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells. Biochim Biophys Acta. 1863. 2891-2903. 2017.
  27. Del Campo A, Roldán J, Verdejo HE, Zalaquett R, Becerra E, Navarro-Marquez M, Mellado R, Lavandero S, Corbalán R, García L, Chiong M. Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation. J Cardiol. 70. 578-583. 2017.
  28. Duran J, Lagos D, Pavez M, Troncoso MF, Ramos S, Barrientos G, Ibarra C, Lavandero S, Estrada M. Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy. Front Pharmacol. 11;8:604. 2017.
  29. Bernal-Sore I, Navarro-Marquez M, Osorio-Fuentealba C, Díaz-Castro F, Del Campo A, Donoso-Barraza C, Porras O, Lavandero S, Troncoso R. Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells. Mol Cell Endocrinol. pii: S0303-7207. 2017.
  30. Peña-Oyarzun D, Troncoso R, Kretschmar C, Hernando C, Budini M, Morselli E, Lavandero S, Criollo A. Hyperosmotic stress stimulates autophagy via polycystin-2. Oncotarget. 8 55984-55997. 2017.
  31. Davidson SM, Riquelme JA, Takov K, Vicencio JM, Boi-Doku C, Khoo V, Doreth C, Radenkovic D, Lavandero S, Yellon DM. Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro. J Cell Mol Med. [Epub ahead of print). 2017.
  32. Rame JE, Lavandero S. Subcellular Remodeling of the T-Tubule Membrane System: The Limits of Myocardial Recovery Revealed?. Circulation. 135. 1646-1650. 2017.
  33. Torrealba N, Aranguiz P, Alonso C, Rothermel BA, Lavandero S. Mitochondria in Structural and Functional Cardiac Remodeling. Adv Exp Med Biol. 982. 277-306. 2017.
  34. Garrido V, Mendoza-Torres E, Riquelme JA, Díaz A, Pizarro M, Bustamante M, Chavez MN, Ocaranza MP, Mellado R, Corbalan R, Allende ML, Lavandero S. Novel Therapies Targeting Cardioprotection and Regeneration. Curr Pharm Des. 23. 2592-2615. 2017.
  35. Gabrielli L, Ocaranza MP, Sitges M, Kanacri A, Saavedra R, Sepulveda P, Sepulveda L, Rossel V, Zagolin M, Verdejo HE, Baraona F, Zalaquett R, Chiong M, Lavandero S, Castro PF. Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension. Echocardiography. 34. 53-60. 2017.
  36. Norambuena-Soto I, Núñez-Soto C, Sanhueza-Olivares F, Cancino-Arenas N, Mondaca-Ruff D, Vivar R, Díaz-Araya G, Mellado R, Chiong M. Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators. Biosci Trends. 11, 154-162. 2017.
  37. Parra V, Rothermel BA. Calcineurin signaling in the heart: The importance of time and place. J Mol Cell Cardiol. 103. 121. 2017.
  38. Peña-Cerda M, Arancibia-Radich J, Valenzuela-Bustamante P, Pérez-Arancibia R, Barriga A, Seguel I, García L, Delporte C. Phenolic composition and antioxidant capacity of Ugni molinae Turcz. leaves of different genotypes.  Food Chem. Jan 15;215:219-27. 2017.
  39. Del Campo M, Zhong TY, Tampe R, García L, Lagos N. Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: Negative health consequences. Toxicon. Feb; 126:23-31. 2017.