Publicaciones 2016

  1. Bravo-Sagua R, López-Crisosto C, Parra V, Rodriguez-Peña M, Rothermel BA, Quest AF, Lavandero S. mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling. Sci Rep, 6, 36394. 2016.
  2. Ortiz R, Díaz J, Díaz N, Lobos-Gonzalez L, Cárdenas A, Contreras P, Díaz MI, Otte E, Cooper-White J, Torres V, Leyton L, Quest AF. Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. Oncotarget, 7(26), 40571-40593. 2016.
  3. Orellana-Manzano A, O’Ryan MG, Lagomarcino AJ, George S, Muñoz MS, Mamani N, Serrano CA, Harris PR, Ramilo O, Mejías A, Torres JP, Lucero Y, Quest AF. Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children. Front Cell Infect Microbiol, 6, 121. 2016.
  4. Barrera MJ, Aguilera S, Castro I, Cortés J, Bahamondes V, Quest AFG, Molina C, González S, Hermoso M, Urzúa U, Leyton C, González MJ. Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren’s syndrome patients. J Autoimmun. 75, 68-81. 2016.
  5. Guerrero AR, Oyarzun-Ampuero F, Hassan N, Corvalán AH, Quest AF, Kogan MJ. Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy. Curr Pharm Des. 39, 5988-5997. 2016.
  6. Riquelme JA, Chavez MN, Mondaca-Ruff D, Bustamante M, Vicencio JM, Quest AF, Lavandero S.    Therapeutic targeting of autophagy in myocardial infarction and heart failure. Expert Rev Cardiovasc Ther. 9, 1007-19. 2016.
  7. Alvarez A, Lagos-Cabré R, Kong M, Cárdenas A, Burgos-Bravo F, Schneider P, Quest AF, Leyton L. Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration. Biochim Biophys Acta. 1863, 2175-88. 2016.
  8. Silva P, Mendoza P, Rivas S, Díaz J, Moraga C, Quest AF, Torres VA. Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis. Oncotarget. 20, 29548-62. 2016.
  9. Shaikh S, Troncoso R, Criollo A, Bravo-Sagua R, García L, Morselli E, Cifuentes M, Quest AF, Hill JA, Lavandero S. Regulation of cardiomyocyte autophagy by calcium. Am J Physiol Endocrinol Metab. 310, E587-E596, 2016.
  10. Ferreccio C, Roa JC, Bambs C, Vives A, Corvalán AH, Cortés S, Foerster C, Acevedo J, Huidobro A, Passi A, Toro P, Covacevich Y, de la Cruz R, Koshiol J, Olivares M, Miquel JF, Cruz F, Silva R, Quest AF, Kogan MJ, Castro PF, Lavandero S. Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024. BMC Public Health. 16, 122. 2016.
  11. Costantino VV, Lobos-Gonzalez L, Ibañez J, Fernandez D, Cuello-Carrión FD, Valenzuela MA, Barbieri MA, Semino SN, Jahn GA, Quest AF, Lopez LA. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 372, 10-23. 2016.
  12. Soto C, Bugueño I, Hoare A, Gonzalez S, Venegas D, Salinas D, Melgar-Rodríguez S, Vernal R, Gamonal J, Quest AF, Pérez-Donoso JM, Bravo D. The Porphyromonas gingivalis O antigen is required for inhibition of apoptosis in gingival epithelial cells following bacterial infection. J Periodontal Res. 51, 518-528. 2016.
  13. Bravo-Sagua R, Mattar P, Díaz X, Lavandero S, Cifuentes M. Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications. Front Physiol. 7, 395. 2016.
  14. Villarroel P, Mattar P, D’Espessailles A, Arrese M, Arreguin A, Fuentes C, Reyes M, Cifuentes M. Calcium sensing receptor effects in adipocytes and liver cells: Implications for an adipose-hepatic crosstalk. Arch Biochem Biophys. 607, 47-54. 2016.
  15. Sebastian Zagmutt, Elba Leiva, Veronica Mujica, Sergio Wehinger. ProtectiveEffect of PropolisExtractonPancreatic Beta Cell UnderOxidative Stress In Vitro. Journal of Food and Nutrition Research. Vol. 4, No. 6. 400-407. 2016.
  16. Del Campo A, Jaimovich E, Tevy MF. Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characterss. Oxid Med Cell Longev. 2016, 9057593. 2016.
  17. Henríquez-Olguín C, Díaz-Vegas A, Utreras-Mendoza Y, Campos C, Arias-Calderón M, Llanos P, Contreras-Ferrat A, Espinosa A, Altamirano F, Jaimovich E, Valladares DM. NOX2 inhibition impairs early muscle gene expression induced by a single exercise bout. Front Physiol. 7, 282. 2016.
  18. Arias-Calderón M, Almarza G, Díaz-Vegas A, Contreras-Ferrat A, Valladares D, Casas M, Toledo H, Jaimovich E, Buvinic S. Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle. Skelet Muscle. 6, 15. 2016.
  19. Espinosa A, Henríquez-Olguín C, Jaimovich E. Reactive oxygen species and calcium signals in skeletal muscle: A crosstalk involved in both normal signaling and disease. Cell Calcium. 60, 172-179. 2016.
  20. Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S. HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med. 90, 206-18. 2016.
  21. Carrasco-Pozo C, Tan KN, Reyes-Ferias M, De La Jara N, Ngo ST, Garcia-Diaz DF, Llanos P, Cires MJ, Borges K. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biol. 9, 229-243.2016.
  22. Valenzuela R, Espinosa A, Llanos P, Hernández-Rodas MC, Barrera C, Vergara D, Romero N, Pérez F, Ruz M, Videla LA. Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil mixture in the liver of mice subjected to high-fat diet. Food Funct. 1, 140-50. 2016.
  23. Rincón-Cervera MA, Valenzuela R, Hernández-Rodas MC, Marambio M, Espinosa A, Mayer S, Romero N, Barrera M Sc C, Valenzuela A, Videla LA. Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues. Nutrition. 11, 1254-67. 2016.
  24. Rincón-Cervera MÁ, Valenzuela R, Hernandez-Rodas MC, Barrera C, Espinosa A, Marambio M, Valenzuela A. Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats. Prostaglandins Leukot Essent Fatty Acids. 111. 25-35. 2016.
  25. Espinosa A, Ahumada U, y Utreras Y. Mecanismos intracelulares por los cuales la obesidad produce resistencia a la insulina. Rev. Cienc. Salud Med. n 2, 63-668, 2016.
  26. Hidalgo C, Arias-Cavieres A. Calcium, Reactive Oxygen Species, and Synaptic Plasticity. Physiology (Bethesda). 31. 201-15. 2016.
  27. Lobos P, Bruna B, Cordova A, Barattini P, Galáz JL, Adasme T, Hidalgo C, Muñoz P, Paula-Lima A. Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers. Neural Plast. 2016, 3456783. 2016.
  28. Sánchez G, Berrios D, Olmedo I, Pezoa J, Riquelme JA, Montecinos L, Pedrozo Z, Donoso P. Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death. PLoS One. 11(8), 11, e0161068. 2016.
  29. Riquelme JA, Westermeier F, Hall AR, Vicencio JM, Pedrozo Z, Ibacache M, Fuenzalida B, Sobrevia L, Davidson SM, Yellon DM, Sánchez G, Lavandero S. Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism. Pharmacol Res 103, 318-27. 2016.
  30. Becerra R, Román B, Di Carlo MN, Mariangelo JI, Salas M, Sanchez G, Donoso P, SchinellaGR,Vittone L, Wehrens XH, Mundiña-Weilenmann C, Said M. Reversible redox modifications ofryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J PhysiolHeart Circ Physiol, 311, H713-24. 2016.
  31. Campos T, Ziehe J, Fuentes-Villalobos F, Riquelme O, Peña D, Troncoso R, Lavandero S, Morin V, Pincheira R, Castro AF. Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival. Biochim. Biophys. Acta-Mol. Cell Res. 1863, 1200-7. 2016.
  32. Rosas C, Oróstica L, Poblete C, Carvajal R, Gabler F, Romero C, Lavandero S, Vega M. Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells. Reprod Sci. 3, 761-70. 2016.
  33. Pizarro M, Troncoso R, Martínez GJ, Chiong M, Castro PF, Lavandero S. Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity. Toxicology 370. 41-48. 2016.
  34. Choi SY, Lee HH, Lee JH, Ye BJ, Yoo EJ, Kang HJ, Jung GW, An SM, Lee-Kwon W, Chiong M, Lavandero S, Kwon HM. TonEBP suppresses IL-10-mediated immunomodulation. Sci Rep. 6, 25726, 2016.
  35. Klionsky DJ, Criollo A, Lavandero S. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12, 443. 2016.
  36. Vivar R, Humeres C, Muñoz C, Boza P, Bolivar S, Tapia F, Lavandero S, Chiong M, Diaz-Araya G. FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation. Biochim. Biophys. Acta-Mol. Cell Res. 1863, 128-38 . 2016.
  37. Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S. BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism. Autophagy. 12, 287-296. 2016.
  38. Vásquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA, Lavandero S. Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 594, 509-525, 2016.
  39. Díaz A, Humeres C, González V, Gómez MT, Montt N, Sanchez G, Chiong M, García L. Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death. Biochem Biophys Res Commun. 467, 451-7. 2016.
  40. Verdejo HE, Becerra E, Zalaquet R, Del Campo A, Garcia L, Troncoso R, Chiong M, Marin A, Castro PF, Lavandero S, Gabrielli L, Corbalán R. Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients. Echocardiography. 33, 242-248. 2016.
  41. Palacios J, Cifuentes F, Valderrama JA, Benites J, Ríos D, González C, Chiong M, Cartes-Saavedra B, Lafourcade C, Wyneken U, González P, Owen GI, Pardo F, Sobrevia L, Buc Calderon P. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta. Oxid Med Cell Longev. 2016, 3939540. 2016.
  42. Torres G, Morales PE, García-Miguel M, Norambuena-Soto I, Cartes-Saavedra B, Vidal-Peña G, Moncada-Ruff D, Sanhueza-Olivares F, San Martín A, Chiong M. Glucagon-like eptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochem Pharmacol. 104, 52-61. 2016.
  43. Morales CR, Li DL, Pedrozo Z, May HI, Jiang N, Kyrychenko V, Cho GW, Kim SY, Wang ZV, Rotter D, Rothermel BA, Schneider JW, Lavandero S, Gillette TG, Hill JA. Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression. Sci Signal. Apr 5;9(422):ra34. 2016.
  44. Martinez-Aguayo A, Campino C, Baudrand R, Carvajal CA, García H, Aglony M, Bancalari R, García L, Loureiro C, Vecchiola A, Tapia-Castillo A, Valdivia C, Sanhueza S, Fuentes CA, Lagos CF, Solari S, Allende F, Kalergis AM, Fardella CE. Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension. J Hypertens. Sep;34(9):1808-14. 2016.
  45. Duran J, Oyarce C, Pavez M, Valladares D, Basualto-Alarcon C, Lagos D, Barrientos G, Troncoso MF, Ibarra C, Estrada M. GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. PLoS One. Dec 15;11(12):e0168255. 2016.
  46. Humeres C, Vivar R, Boza P, Muñoz C, Bolivar S, Anfossi R, Osorio JM, Olivares-Silva F, García L, Díaz-Araya G. Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro.  J Mol Cell Cardiol. Oct 27. pii: S0022-2828(16)30392-3. 2016.