Referencias Selectas
TSP-1 Endothelial Signaling Impairs Brain Angiogenesis in Preeclampsia. Escudero-Guevara E, Troncoso F, Sandoval H, Vargas C, Alarcón M, Mistry HD, Kurlak LO, Vatish M, Moore-Carrasco R, Acurio J, Escudero C. Hypertension. 2026 Aug 27. doi: 10.1161/HYPERTENSIONAHA.126.27749.
Isolation and Culture of Mouse Brain Microvascular Endothelial Cells. Escudero-Guevara E, Sandoval H, Acurio J, Troncoso F, Moore-Carrasco R, Escudero C. J Vis Exp. 2026 Jul 17;(233). doi: 10.3791/70909.
Tumor-muscle communication in cancer-associated cachexia (Review). Berríos-Contreras L, Meza-Valenzuela M, Brown N, Valenzuela C, Busquets S, López-Soriano FJ, Quest AF, Moore-Carrasco R. Oncol Lett. 2026 Mar 5;31(5):160. doi:10.3892/ol.2026.15513.
Synthesis and in vitro antitumor evaluation of novel 3,4-dihydropyrimidinone-vorinostat hybrids against gastric and breast cancer cell lines. Rios EAM, Pereira GMSDM, D’Oca MGM, Dea CM, Santos ERFB, Rampon DS, Santos LS, Nachtigall FM, Guzman L, Moore-Carrasco R, Rebolledo-Miraf D, D’Oca CRM. RSC Adv. 2026 Mar 16;16(16):14027-14035. doi: 10.1039/d6ra00701e.
Extracellular Vesicles (EVs) Derived from Senescent Endothelial Cells Promote Platelet Activation. Venturini W, Cayo A, Diaz-Serrano G, Sanhueza S, Huilcaman R, Méndez D, Rebolledo-Mira D, Silva-Pereira C, Torres-Orellana F, Troncoso F, Escudero C, Fuentes E, Quest AFG, Valenzuela C, Amaro JCT, Brown NE, Moore-Carrasco R. Int J Mol Sci. 2026 Jan 15;27(2):869. doi: 10.3390/ijms27020869.
On-demand dual-stimuli-responsive hydrogels for localized and sustained delivery of MP-L [I5R8] to treat bacterial wound infections. Guerrero M, Marican A, Rafael D, Andrade F, Moore-Carrasco R, Vijayakumar S, Salinas P, Cabrera-Barjas G, Lara J, Durán-Lara EF. Colloids Surf B Biointerfaces. 2025 Jul;251:114636. doi: 10.1016/j.colsurfb.2025.114636.
Platelet Content from Acute Myocardial Infarction Patients: Elevated Levels of IL-6 and IL-8 and their impact on Endothelial Nitric Oxide Production. Arauna D, Chandia E, Nova-Lamperti E, Radojkovic C, Fuentes E, Palomo I, Guzmán-Gutiérrez E, Moore-Carrasco R, Aguayo C. Atherosclerosis. 2025 Apr;403:119119. doi: 10.1016/j.atherosclerosis.2025.119119.
Shortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity. Valero P, Silva K, Valenzuela-Hinrichsen A, Vásquez A, Espinoza F, Lira F, Cornejo M, Fuentes G, González D, Moore-Carrasco R, van der Beek EM, Hillebrands JL, van Goor H, Grismaldo A, Sobrevia L. J Physiol. 2026 Jun;604(11):4092-4114. doi: 10.1113/JP286955.
Synthesis of novel fatty acid 3,4-dihydropyrimidin-2-(1H)-one and antitumoral activity against breast and gastric cancer cells. Rios EAM, Dea CM, Dos Santos ERFB, D’Oca MGM, Rampon DS, Nachtigall FM, Santos LS, Guzman L, Moore-Carrasco R, Rebolledo-Mira D, D’Oca CRM. RSC Adv. 2024 Jul 22;14(32):22981-22987. doi: 10.1039/d4ra03292f.
Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy. Cayo A, Venturini W, Rebolledo-Mira D, Moore-Carrasco R, Herrada AA, Nova-Lamperti E, Valenzuela C, Brown NE. Int J Mol Sci. 2023 May 26;24(11):9284. doi: 10.3390/ijms24119284.
Platelets and endothelial dysfunction in gestational diabetes mellitus. Valero P, Cornejo M, Fuentes G, Wehinger S, Toledo F, van der Beek EM, Sobrevia L, Moore-Carrasco R. Acta Physiol (Oxf). 2023 Apr;237(4):e13940. doi: 10.1111/apha.13940.
Platelets, a Key Cell in Inflammation and Atherosclerosis Progression. Huilcaman R, Venturini W, Fuenzalida L, Cayo A, Segovia R, Valenzuela C, Brown N, Moore-Carrasco R. Cells. 2022 Mar 17;11(6):1014. doi: 10.3390/cells11061014.
mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership. Cayo A, Segovia R, Venturini W, Moore-Carrasco R, Valenzuela C, Brown N. Int J Mol Sci. 2021 Jul 29;22(15):8149. doi: 10.3390/ijms22158149.
Gestational diabesity and foetoplacental vascular dysfunction. Cornejo M, Fuentes G, Valero P, Vega S, Grismaldo A, Toledo F, Pardo F, Moore-Carrasco R, Subiabre M, Casanello P, Faas MM, van Goor H, Sobrevia L. Acta Physiol (Oxf). 2021 Aug;232(4):e13671. doi: 10.1111/apha.13671.
Endothelial transmigration of platelets depends on soluble factors released by activated endothelial cells and monocytes. Huilcaman R, Veliz-Olivos N, Venturini W, Olate-Briones A, Treuer AV, Valenzuela C, Brown N, Moore-Carrasco R. Platelets. 2021 Nov 17;32(8):1113-1119. doi: 10.1080/09537104.2021.1902970.
Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro. Venturini W, Olate-Briones A, Valenzuela C, Méndez D, Fuentes E, Cayo A, Mancilla D, Segovia R, Brown NE, Moore-Carrasco R. Int J Mol Sci. 2020 May 6;21(9):3287. doi: 10.3390/ijms21093287.
SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells. Valenzuela CA, Quintanilla R, Olate-Briones A, Venturini W, Mancilla D, Cayo A, Moore-Carrasco R, Brown NE. Int J Mol Sci. 2019 Oct 24;20(21):5292. doi: 10.3390/ijms20215292.
Personas
Investigador Principal
Rodrigo Moore-Carrasco PhD.
Investigadores Asociados
Nelson Brown Vega MD. PhD.
Claudio Valenzuela Cabezas PhD.
Colaboradores Nacionales
Andrew Quest, Universidad de Chile
Carlos Escudero, Universidad del Bío-Bío
Luis Sobrevia, Pontificia Universidad Católica de Chile
Esteban Dúran Lara, Universidad de Talca
Eduardo Fuentes Quinteros, Universidad de Talca
Colaboradores Internacionales
Silvia Busquets, Universidad de Barcelona, España
Francisco Lopez Soriano, Universidad de Barcelona, España
Alumnos de Doctorado
Lily Berrios, Doctorado en Ciencias Biomédicas, Universidad de Talca
Cristian Orellana, Doctorado en Ciencias Biomédicas, Universidad de Talca
Esthefanny Escudero, Doctorado en Ciencias Biomédicas, Universidad de Talca
Hermes Sandoval, Doctorado en Ciencias Biomédicas, Universidad de Talca
Alumnos de Magíster
Solange Besoain, Megíster en Ciencias Biomédicas, Universidad de Talca
Apoyo Técnico Profesional
Gabriela Moya, Ingeniera en Biotecnología
