Selected references

Selected peer-reviewed publications (selected from over 221): Publications (2011-up to date): 111, hIndex Google Scholar: 46, Total citations Google Scholar:11.761

Foncea R, Andersson M, Ketterman A, Blakesley V, Sapag-Hagar M, Sugden PH, LeRoith D, Lavandero S. Insulin-like growth factor-1 rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. Journal ofBiologicalChemistry 1997; 272:19115-19124. PMID: 9235900

Ibarra C, Estrada M, Carrasco L, Chiong M, Liberona JL, Cárdenas C, Díaz-Araya G, Jaimovich E, Lavandero S. Insulin-like growth factor-1 induces an inositol 1,4,5-triphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. Journal ofBiologicalChemistry 2004; 279: 7554-7565.PMID: 14660553

Ocaranza MP, Godoy I, Jalil JE, Varas M, Ramirez C, Castro PF, Diaz-Araya G, Lavandero S. Enalapril attenuates down-regulation of ACE2 in the late phase of ventricular dysfunction in myocardial infarcted rat. Hypertension 2006; 48: 572-578.PMID: 16908757

Criollo A, Maiuri MC, Tasdemir E, Vitale I, Fiebig AA, Andrews D, Molgó J, Díaz J, Lavandero S, Harper F, Pierron G, di Stefano D, Rizzuto R, Szabadkai G, Kroemer G. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death & Differentiation 2007; 14:1029-1039. PMID: 17256008

Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C, Lavandero S. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovascular Research 2008; 77: 387-397.PMID: 18006463

Vicencio JM, Ortiz C, Criollo A, Jones AWE, Kepp O, Galluzzi L, Joza N, Vitale I, Morselli E, Tailler M, Castedo M, Maiuri MC, Molgó J, Szabadkai G, Lavandero S#, Kroemer G#. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death& Differentiation 2009; 16:1006-17. #These authors share senior co-authorship. PMID: 19325567

Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early ER stress. Journal of Cell Science 2011; 124: 2143-2152. PMID: 21628424

Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy. Journal of Clinical Investigation 2012; 122:1109-1118. PMID: 22326951

Ibarra C, Vicencio JM, Estrada M, Lin Y, Rocco P, Rebellato P, Munoz JP, Garcia-Prieto J, Quest AFG, Chiong M, Davidson SM, Bulatovic I, Grinnemo KH, Larsson O, Szabadkai G, Uhlén P, Jaimovich E, Lavandero S. Local control of nuclear Ca2+ signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal IGF-1 receptors. Circulatation Research 2013; 112:236-245. PMID: 23118311

Parra V, Verdejo HE, Iglewski M, del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFkB-Opa-1 signaling pathway. Diabetes 63:75-88, 2014.PMID: 24009260

Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang M, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen P, Ferdous A, Gillette TG, Scherer PE, Hill JA. Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. Cell 156, 1179-1192, 2014.PMID: 24630721.

Gatica D, Chiong M, Lavandero S, Klionsky D. Molecular mechanisms of autophagy in the cardiovascular system. Circulation Research 116:456-467, 2015.PMID: 25634969.

Lavandero S, Chiong M, Rothermel BA, Hill JA. Autophagy in cardiovascular biology. Journal of Clinical Investigation 125: 55-64, 2015.PMID: 25654551.

Pedrozo Z, Criollo A, Battiprolu PK, Morales CR, Contreras A, Fernández C, Jiang N, Luo X, Caplan MJ, Somlo S, Rothermel BA, Gillette TG, Lavandero S*, Hill JA*. Polycystin-1 is a cardiomyocyte mechanosensor that governs L-type Ca2+ channel protein stability. Circulation 131:2131-2142, 2015. PMID: 25888683. #These authors share senior co-authorship.

Westermeier F, Navarro-Marquez M, López-Crisosto C, Bravo-Sagua R, Quiroga C, Bustamante M, Verdejo HE, Zalaquett R, Ibacache M, Parra V, Castro PF, Rothermel BA, Hill JA, Lavandero S. Defective insulin signaling in diabeticcardiomyopathy and mitochondrial dynamics. Biochimica & Biophysic Acta Molecular& Cellular Research 1853:1113-1118, 2015.PMID: 25686534.

Lopez-Crisosto C, Bravo-Sagua R, Rodriguez-Peña M. Mera C, Castro PF, Quest, AF, Rothermel BA, Cifuentes M, Lavandero S. ER-to-mitochondria miscommunication and metabolic diseases. Biochimica & BiophysicActa – Molecular Basis of Disease 1852: 2096-2105, 2015. PMID: 26171812.

Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S. BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism. Autophagy 12:287-296, 2016.PMID: 26654586
Vasquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA, Lavandero S. Mitochondrial dynamics, mitophagy and cardiovascular disease. Journal of Physiology 594:509-525, 2016.PMID: 26537557.

Morales CR, Li DL, Pedrozo Z, May HI, Jiang N, Kyrychenko V, Cho G, Kim SY, Wang ZV, Rotter D, Rothermel BA, Schneider JW, Lavandero S, Gillette TG, Hill JA. lnhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression. Science Signaling 9: ra34, 2016, 2016. PMID: 27048565.

Bravo-Sagua R, López-Crisosto C, Parra V, Rodríguez-Peña M, Rothermel BA, Quest AFG, Lavandero S. mTORC1 inhibitorrapamycin and ER stressortunicamycin induce differential patterns of ER mitochondria coupling, ScientificReports 6:36394, 2016. PMID: 27808250.

Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AFG, Lavandero S. Calcium transport and signaling in mitochondria. Comprehensive Physiology (in press, 2017).

Lopez-Crisosto C, Pennanen C, Vasquez-Trincado C, Morales P, Bravo-Sagua R, Quest AFG, Chiong M, Lavandero S. Sarcoplas micreticulum-mitochondria communication in cardiovascular pathophysiology. Nature Reviews Cardiology(in press, 2017).