Publications 2013

A Aguirre, K F. Shoji, J C. Sáez, M Henríquez, A FG. Quest. FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7). J Cell Physiol 228: 485-493, 2013

C Ibarra, J M. Vicencio, M Estrada, Y Lin, P Rocco, P Rebellato, J P. Muñoz, J Garcia-Prieto, A FG. Quest, M Chiong, S M. Davidson, I Bulatovic, K H. Grinnemo, O Larsson, G Szabadkai, P Uhlén, E Jaimovich, S Lavandero. Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors. Circ Res 112: 236-245, 2013

R Bravo, V Parra, D Gatica, A E. Rodríguez, N Torrealba, F Paredes, Z V. Wang, A Zorzano, J A. Hill, E Jaimovich, A FG. Quest, S Lavandero. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Moll Biol 301: 215-290, 2013

A FG. Quest, L Lobos, S Nuñez, C Sanhueza, J G. Fernández, A Aguirre, D Rodríguez, L Leyton, V Torres. The Caveolin-1 connection to cell death and survival. Curr Mol Med 13: 266-281, 2013

M Chiong, M Pablo, G Torres, T Gutiérrez, L García, M Ibacache, L Michea. Influence of glucose metabolism on vascular smooth muscle cell proliferation. Vasa 42: 8-16, 2013

R Vivar, C Humeres, P Ayala, I Olmedo, M Catalán, L García, S Lavandero, G Díaz-Araya. TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochim Biophys Acta 1832: 754-762, 2013

S S. Smaili, A FG. Quest, C Hetz, S Lavandero. Editorial: signaling in cell death, survival, proliferation and degeneration. Curr Mol Med 13: 239-240, 2013

P Battiprolu, C López-Crisosto, Z Wang, A Nemchenko, S Lavandero, J A. Hill. Diabetic cardiomyopathy and metabolic remodeling of the heart. Life Sci 92: 609-615, 2013

G Mercado, P Valdés, C Hetz. An ERcentric view of Parkinson’s disease. Trends Mol Med 19: 165-175, 2013

R Vidal, C Hetz. Unspliced XBP1 controls autophagy through FoxO1. Cell Res 23: 463-464, 2013

V Parra, F Moraga, J Kuzmicic, C López-Crisosto, R Troncoso, N Torrealba, A Criollo, J Díaz, B Rothermel, A FG. Quest, S Lavandero. Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death. Biochim Biophys Acta 1832: 1334-1344, 2013

M Kong, N Muñoz, A Valdivia, A Alvarez, R Herrera, A Cárdenas, P Schneider, K Burridge, A FG. Quest, L Leyton. Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochim Biophys Acta 1833: 1409-1420, 2013

F Osorio, A Contreras, F Altamirano, A Espinosa, L Qing, N Wenyan, S Lavandero, A Klip, E Jaimovich. Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells. Diabetes 62: 1519-1526, 2013

G Jorquera, F Altamirano, A Contreras-Ferrat, G Almarza, S Buvinic, V Jacquemond, E Jaimovich, M Casas. Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity. J Cell Sci 126: 1189-1198, 2013

Z Pedrozo, N Torrealba, C Fernández, D Gatica, B Toro, C Quiroga, A Rodríguez, G Sanchez, T Gillette, J Hill, P Donoso, S Lavandero. Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy. Cardiovasc Res 98: 277-285, 2013

E Antileo, C Garri, V Tapia, J P. Muñoz, M Chiong, F Nualart, S Lavandero, J Fernández, M T. Núñez. Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells. Am J Physiol Gastrointest Liver Physiol 304: G655-G661, 2013

M Ronjat, J P. Finkelstein, P Llanos, L Montecinos, H Bichraoui, M De Waard, C Hidalgo, R Bull. Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine. Cell Calcium 53: 357-365, 2013

L Lobos, L Aguilar, J Díaz, N Díaz, H Urra, V Torres, V Silva, C Fitzpatrick, A Lladser, K Hoek, L Leyton, A FG. Quest. E-cadherin determines caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells. Pigment Cell Melanoma Res 26: 555-570, 2013

M J. Barrera, V Bahamondes, D Sepúlveda, A FG. Quest, I Castro, J Cortés, S Aguilera, U Urzúa, C Molina, P Pérez, P Ewert, C Alliende, M A. Hermoso, S González, C Leyton, M J. González. Sjögren’s syndrome and the epithelial target: acomprehensive review. J Autoimmun 42: 7-18, 2013

I Castro, D Sepúlveda, J Cortés, A FG. Quest, M J. Barrera, V Bahamondes, S Aguilera, U Urzúa, C Alliende, C Molina, S González, M A. Hermoso, L Leyton, M J. González. Oral dryness in Sjögren’s syndrome patients. Not just a question of water. Autoimmun Rev 12: 567-574, 2013

P Ormazabal, C Romero, F Gabler, A FG. Quest, M Vega. Decreased Phosphorylation of Y14Caveolin-1 in Endometrial Tissue of Polycystic Ovary Syndrome Patients may be Related with an Insulin Resistant State in this Tissue. Horm Metab Res 45: 291-296, 2013

J Váldes, S Flores, E Fuentes, C Osorio, E Jaimovich, A Molina. IGF-1 induces IP(3) dependent calcium signal involved in the regulation of myostatin gene expression mediated by NFAT during myoblast differentiation. J Cell Physiol 228: 1452-1456, 2013

R Troncoso, J Díaz-Elizondo, S Espinoza, M Navarro-Marquez, A Oyarzún, J Riquelme, I García-Carvajal, G Díaz-Araya, L García, J A. Hill, S Lavandero. Regulation of cardiac autophagy by insulin-like growth factor 1. IUBMB Life 65: 593-601, 2013

R Bravo-Sagua, A Rodríguez, J Kuzmicic, T Gutierrez, C López-Crisosto, C Quiroga, J Díaz-Elizondo, M Chiong, T G. Gillette, B A. Rothermel, S Lavandero. Cell death and survival through the endoplasmic reticulum-mitochondrial axis. Curr Mol Med 13: 317-329, 2013

H Cornejo, C Hetz. The unfolded protein response in Alzheimer’s disease. Semin Immunopathol 35: 277-292, 2013

K Castillo, M Nassif, V Valenzuela, F Rojas, S Matus, G Mercado, F Court, B Van Zundert, C Hetz. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 9: 1-13, 2013

A Tapia-Pizarro, F Argandoña, W A. Palomino, L Devoto. Human chorionic gonadotropin (hCG) modulation of TIMP1 secretion by human endometrial stromal cells facilitates extravillous trophoblast invasion in vitro. Hum Reprod 28: 2215-2227, 2013

C A. Basualto, R Maas, E Jaimovich, M Estrada. Hot topics in endocrine and endocrine-related diseases. 28: 238-264, 2013

A Paula-Lima, C Hidalgo. Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?. Front Cell Neurosci 7: 1-3, 2013

Y Fan, G Abrahamsen, R Mills, C Calderón, J Y. Tee, L Leyton, W Murrell, J Cooper-White, J J. McGrath, A Mackay-Sim. Focal adhesion dynamics are altered in schizophrenia. Biol Psychiatry 74: 418-426, 2013

P Mendoza, R Ortiz, J Diaz, A FG. Quest, L Leyton, S Dwayne, V Torres. Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.. J Cell Sci 126: 3835-3847, 2013

M Valenzuela, D Bravo, J Canales, C Sanhueza, N Díaz, O Almarza, H Toledo, A FG. Quest. Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity. J Infect Dis 208: 1131-1141, 2013

R Herrera-Molina, A Valdivia, M Kong, A Alvarez, A Cárdenas, A FG. Quest, L Leyton. Thy-1-interacting molecules and cellular signaling in cis and trans. Int Rev Cell Mol Biol 305: 163-216, 2013

W Palomino, F Argandoña, R Azúa, P Kohen, L Devoto. Complement c3 and decay-accelerating factor expression levels are modulated by human chorionic gonadotropin in endometrial compartments during the implantation window. Reprod Sci 20: 1103-1110, 2013

C Wilson, A Contreras-Ferrat, N Venegas, C Osorio-fuentealba, M Pávez, K Montoya, J Durán, R Maass, S Lavandero, M Estrada. Testosterone increases GLUT4-dependent glucose uptake in cardiomyocytes. J Cell Physiol 228: 2399-2407, 2013

S Matus, E López, V Valenzuela, M Nassif, C Hetz. Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis. PLoS One 8: e66672-e66672, 2013

A Espinosa, C Campos, A Díaz-Vegas, J Galgani, N Juretic, C Osorio-Fuentealba, J L. Bucarey, G Tapia, R Valenzuela, A Contreras-Ferrat, P Llanos, E Jaimovich. Insulin-dependent H2O2 production is higher in muscle fibers of mice fed with a high-fat diet. Int J Mol Sci 14: 15740-15754, 2013

C Basualto-Alarcón, G Jorquera, F Altamirano, E Jaimovich, M Estrada. Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy. Med Sci Sports Exerc 45: 1712-1720, 2013

F Simon, D Varela, C Cabello-Verrugio. Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans. Cell Signal 25: 1614-1624, 2013

P Ormazabal, C Romero, A FG. Quest, M Vega. Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells. Horm Metab Res 45: 640-645, 2013

K Castillo, V Valenzuela, S Matus, M Nassif, M Oñate, Y Fuentealba, G Encina, T Irrazabal, G Parsons, F A. Court, B L. Schneider, D Armentano, C Hetz. Measurement of autophagy flux in the nervous system in vivo. Cell Death Dis 4: e917-e917, 2013

S Matus, V Valenzuela, D B. Medinas, C Hetz. ER Dysfunction and Protein Folding Stress in ALS. Int J Cell Biol 2013: 674751-674751, 2013

D B. Medinas, C Hetz. Proteostasis impairment: at the intersection between Alzheimer’s disease and diabetes. Cell Metab 18: 771-772, 2013

V H. Cornejo, P Pihán, R Vidal, C Hetz. Role of the unfolded protein response in organ physiology: lessons from mouse models. IUBMB Life 65: 962-975, 2013

H Urra, E Dufey, F Lisbona, D Rojas-Rivera, C Hetz. When ER stress reaches a dead end. Biochim Biophys Acta 1833: 3507-3517, 2013

D Valladares, G Almarza, A Contreras, M Pavez, S Buvinic, E Jaimovich, M Casas. Electrical stimuli are anti-apoptotic in skeletal muscle via extracellular ATP. Alteration of this signal in Mdx mice is a likely cause of dystrophy. PLoS One 8: e75340-e75340, 2013

F Altamirano, D Valladares, C Henríquez-Olguín, M Casas, J R. López, P D. Allen, E Jaimovich. Nifedipine treatment reduces resting calcium concentration, oxidative and apoptotic gene expression, and improves muscle function in dystrophic mdx mice. PLoS One 8: e81222-e81222, 2013

P Kohen, S Henríquez, C Rojas, P M. Gerk, W A. Palomino, J F. Strauss, L Devoto. 2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity. Fertil Steril 100: 1397-1404, 2013

C Quiroga, D Gatica, F Paredes, R Bravo, R Troncoso, Z Pedrozo, A E. Rodríguez, B Toro, M Chiong, J M. Vicencio, C Hetz, S Lavandero. Herp depletion protects from protein aggregation by up-regulating autophagy. Biochim Biophys Acta 1833: 3295-3305, 2013

S Lavandero, R Troncoso, B A. Rothermel, W Martinet, J Sadoshima, J A. Hill. Cardiovascular autophagy: Concepts, controversies, and perspectives. Autophagy 9: 1455-1466, 2013

C Hetz. The biological meaning of the UPR. Nat Rev Mol Cell Biol 14: 404-404, 2013

A Corvalan. Epigenetics in the pathogenesis and early detection of gastric cancer. Rev Med Chil 141: 1570-1577, 2013