Selected references

Insulin-like growth factor-1 rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. Foncea R, Andersson M, Ketterman A, Blakesley V, Sapag-Hagar M, Sugden PH, LeRoith D, Lavandero S. Journal of Biological Chemistry 272:19115-19124, 1997.

Effect of inhibitors of signal transduction on IGF-1-induced-protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes. Lavandero S, Foncea R, Pérez V, Sapag-Hagar M. FEBS Letters 422: 193-196, 1998.

Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy. Ebensperger R, Acevedo E, Meléndez J, Corbalán R, Acevedo M, Sapag–Hagar M, Jalil JE, Lavandero S. Biochemical & Biophysical Research Communication 422: 193-196, 1998.

IGF-1 regulates apoptosis of cardiac myocytes induced by osmotic stress. Morales MP, Gálvez A, Eltit JM, Ocaranza P, Díaz-Araya G, Lavandero S. Biochemical & Biophysical Research Communication 270:1029-1035, 2000.

A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes. Gálvez A, Morales MP, Eltit JM, Ocaranza P, Carrasco L, Campos X, Sapag-Hagar M, Díaz-Araya G, Lavandero S. Cell & Tissue Research 304: 279-285, 2001.

Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat. Oliveri C, Ocaranza MP, Campos X, Lavandero S, Jalil JE. Hypertension 38: 650-654, 2001.

Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Castro P, Greig D, Pérez O, Moraga F, Chiong M, Díaz-Araya G, Padilla I, Nazal C, Jalil J, Vukasovic JL, Moreno M, Corbalán R, Lavandero S. American Journal of Cardiology 92: 16-19, 2003.

Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol. Gálvez AS, Ulloa JA, Chiong M, Criollo A, Eisner V, Barros LF, Lavandero S. Journal of Biological Chemistry 278: 38484-38494, 2003.

Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats. Ocaranza MP, Diaz-Araya G, Carreno JE, Munoz D, Riveros JP, Jalil JE, Lavandero S. American Journal of Physiology Heart Circulation Physiology 286:H498-H506, 2004.

Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. Ibarra C, Estrada M, Carrasco L, Chiong M, Liberona JL, Cardenas C, Diaz-Araya G, Jaimovich E, Lavandero S. Journal of Biological Chemistry 279:7554-7565, 2004.

Increased aortic NADPH oxidase activity in rats with genetically high angiotensin converting enzyme levels. Jalil JE, Pérez A, Ocaranza MP, Bargetto J, Galaz A, Lavandero S. Hypertension 46: 1363-1367, 2005

Testosterone induces an intracellular calcium increase by a non-genomic mechanism in cultured rat cardiac myocytes. Vicencio JM, Ibarra C, Estrada M, Chiong M, Soto D, Parra V, Diaz-Araya G, Jaimovich E, Lavandero S. Endocrinology 147:1386-1395, 2006

Enalapril attenuates down-regulation of ACE2 in the late phase of ventricular dysfunction in myocardial infarcted rat. Ocaranza MP, Godoy I, Jalil JE, Varas M, Ramirez C, Castro PF, Diaz-Araya G, Lavandero S. Hypertension 48: 572-578, 2006.

Hyperosmotic stress- dependent NFkB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. Eisner V, Criollo A, Quiroga C, Olea-Azar O, Santibañez JF, Troncoso R, Chiong M, Díaz-Araya G, Foncea R, Lavandero S. FEBS Letters 580:4495-4500, 2006.

Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high ACE levels. Rivera P, Ocaranza MP, Lavandero S, Jalil JE. Hypertension 50:792-798, 2007

Mitochondrial control of cell death induced by hyperosmotic stress. Criollo A, Galluzzi L, Maiuri MC, Tasdemir E, Lavandero S, Kroemer G. Apoptosis 12:3-18, 2007.

Regulation of autophagy by the inositol trisphosphate receptor. Criollo A, Maiuri MC, Tasdemir E, Vitale I, Fiebig AA, Andrews D, Molgó J, Díaz J, Lavandero S, Harper F, Pierron G, di Stefano D, Rizzuto R, Szabadkai G, Kroemer G. Cell Death & Differentiation 14:1029-1039, 2007.

The inositol trisphosphate receptor in the control of autophagy. Criollo A, Vicencio JM, Tasdemir E, Maiuri MC, Lavandero S, Kroemer G. Autophagy 3:350-353, 2007.

Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C, Lavandero S. Cardiovascular Research 77: 387-397, 2008.