Selected References

Hetz C. and Mollereau B. (2014) Disturbance of ER proteostasis in neurodegenerative diseases. Nature Rev Neurosci. 15:233-249.*#
Valdés P., Mercado G., Vidal R., Parsons G., Court F., Molina C., Martinez A., Galleguillos D., Armentano D., Schneider B., and Hetz C. (2014). Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc Natl. Acad. Asci USA. 111:6804-9. *#

Groenendyk J., Peng Z., Dudek E., Fan X., Mizianty M., Dufey E., Urra H., Sepulveda D., Rojas-Rivera D., Lim Y., Han Kim D., Baretta K., Srikanth S., Gwack Y., Ahnn J., Kaufman K., Lee S., Hetz C., Kurgan L. and Michalak M. (2014) Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis. Science Signaling 7: 1-14.* (Cover illustration)

Nassif M., Valenzuela V., Rojas-Rivera D., Vidal R., Matus S, Castillo K., Fuentealba Y., Kroemer G., Levine B., and Hetz C. (2014) Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy. 10: 1256-1271*#. (Cover illustration)

Hetz C. (2013). The biological meaning of the UPR. Nature Rev Mol Cell Biol. 14:404. Journal Club*#

Hetz C., Chevet E., and Harding H. (2013). Targeting the unfolded protein response in disease. Nature Rev Drug Discovery 12:703-719. *#

Acuña A., Esparza M., Kramm C., Beltrán F., Parra A., Cepeda C., Toro C., Vidal R., Hetz C., Concha I., Brauchi S., Levine M. and Castro M. (2013) A failure in energy metabolism and antioxidant uptake precede the onset of Huntington’s disease. Nature Communications. 13:2917.*

Castillo K., Valenzuela V., Matus S., Nassif M., Oñate M, Fuentealba Y. Encina G., Irrazabal T., Parsons G., Court F., Schneider B., Armentano D., and Hetz C. (2013) Measurement of autophagy flux in the nervous system in vivo. Cell Death Dis. 4:e917. *#

Castillo K., Nassif M., Valenzuela V., Rojas F., Matus S., Mercado G., Court F., van Zundert B., and Hetz C. (2013) Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 9:1308-20. *#

Matus S, Lopez E., Valenzuela V., Nasiff M., and Hetz C. (2013) Functional role of the transcription factor ATF4 in the pathogenesis of amyotrophic lateral sclerosis. PloS One 8:e66672.

Rodriguez D., Zamorano S., Lisbona F., Rojas D., Cubillos-Ruiz J., Armisen R., Henriquez D., Urra H., Cheng E., Letek M., Vaisar T., Irrazabal T., Gonzalez-Billault C., Letai A., Pimentel-Muiños F., Kroemer G. and Hetz C.. (2012). BH3-only proteins are part of a regulatory network that control the sustained signaling of the Unfolded Protein Response sensor IRE1. EMBO J. 31(10):2322-35.*#

Vidal R., Figueroa A., Court F., Thielen P., Molina C., Wirth C., Caballero B., Kiffin R., Segura-Aguilar J., Cuervo AM, Glimcher L., and Hetz C. (2012). Targeting the UPR transcription factor XBP1 protects against Huntington’s disease through the regulation of FoxO1 and autophagy. Hum. Mol. Gen. 21(10):2245-62. *#

Rojas-Rivera D, Armisén R., Colombo A., Eguiguren A., Martínez G., Díaz A., Kiviluoto S., Rodríguez D., Patron M., Rizzuto R., Bultynck G., Concha M., Sierralta J., Stutzin A., and Hetz C. (2012). TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Diff. 9:1013-26. *#

Zamorano S., Rojas-Rivera D., Lisbona F., Parra V., Court F., Villegas R., Cheng E., Korsmeyer S., Lavandero S., and Hetz C. (2012) A BAX/BAK and Cyclophilin D-independent Intrinsic Apoptosis Pathway. PLoS One :e37782. *#

Valenzuela V, Collyer E., Armentano D., Parsons G., Court F. and Hetz C. (2012). Activation of the Unfolded Protein Response enhances motor recovery after spinal cord injury. Cell Death Dis. 3, e272 *#

Torres M., Cartier L., Matamala J, Hernandez N., Woehvier U., and Hetz C. (2012). Altered Prion protein expression pattern in CSF as a biomarker for Creutzfeldt-Jakob Disease. PLoS One .7:e36159. *#

Castillo K, Rojas-Rivera D., Lisbona F., Caballero B., Nassif M., Court F., Schuck S., Ibar C., Walter P., Sierralta J., Glavic A., and Hetz C. (2011). BAX inhibitor-1 regulates autophagy by controlling the IRE1a/JNK branch of the unfolded protein response. EMBO J. 4465-78*#

Hetz C. and Glimcher L. (2009). Fine tuning of the Unfolded Protein Response: Assembling the IRE1 interactome. Mol Cell. 35:551-61. *#

Hetz C, Thielen P, Matus S., M Nassif, Court F., Cuervo AM., Martinez G., Kiffin R., R.H. Brown and Glimcher L. (2009). XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes & Dev. 23:2294–2306. (Cover illustration) *#
Commented in Genes Dev. (2009), 23:2294-306.

Lisbona F., Rojas D., Thielen P., Zamorano S., Todd D., Martinon F., Glavic A., Kress C.,, Lin J., Walter P., Reed J., Glimcher L. and Hetz C. (2009). BAX Inhibitor-1 is a negative regulator of the ER stress sensor IRE1. Mol. Cell. 33:679-691.*# (Cover illustration)
Commented in Mol Cell (2009), 33:669-70.