Publicaciones 2012

M. Casas, F Altamirano, E Jaimovich. Myology: Methods and Protocols. 798: 383-393, 2012

R. Herrera-Molina, R Frischknecht, H Maldonado, C Seidenbecher, E Gundelfinger, C Hetz, M Aywiln, P Schneider, A FG. Quest, LL Leyton. Astrocytic α(V)β(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1. PLoS One 7: e34295-e34295, 2012

I. Castro, S Aguilera, I Bronckhausen, C Alliende, A FG. Quest, C Molina, U Urzúa, U Mandel, V Bahamondes, J M. Barrera, M Sánchez, S González, M Hermoso, C Leyton, M J. González. Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren’s syndrome patients. Rheumatology 51: 482-490, 2012

J. Pérez-Donoso, J Monrás, D Bravo, A Aguirre, A FG. Quest, R Osorio, R Aroca, T Chasteen, C Vásquez. Biomimetic, mild chemical synthesis ofCdTe-GSH quantum dots with improved biocompatibility. PLoS One 7: e30741-e30741, 2012

P. K. Battiprolu, B Hojayev, N Jiang, Z Wang, X Luo, M Iglewski, J M. Shelton, P D. Gerard, B A. Rothermel, T G. Gillette, S Lavandero, J A. Hill. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest 122: 1109-1118, 2012

M. Copaja, D Venegas, P Aránguiz, J Canales, R Vivar, Y Ávalos, L García, M Chiong, I Olmedo, M Catalán, L Leyton, S Lavandero, G Díaz-Araya. Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration andviability. Toxicology 294: 42-49, 2012

M. Ibacache, G Sánchez, Z Pedrozo, F Gálvez, C Humeres, G Echevarria, J Duaso, M Hassi, L García, G Díaz-Araya, S Lavandero. Dexmedetomidine preconditioningactivates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart. Biochim Biophys Acta 1822: 537-545, 2012

R.Troncoso, J M. Vicencio, V Parra, A Nemchenko, Y Kawashima, A Del campo, B Toro, P K. Battiprolu, P Aránguiz, M Chiong, S Yakar, T G. Gillette, J A. Hill, E D. Abel, D Leroith, S Lavandero. Energy-preserving effects of IGF-1 antagonizestarvation-induced cardiac autophagy. Cardiovasc Res 93: 320-329, 2012

V. García, P Kohen, C Maldonado, W Sierralta, A Muñoz, C Villarroel, F Strauss, L Devoto. Transient expression of progesterone receptor and cathepsin-l in human granulosa cells during the periovulatory period. Fertil Steril 97: 707-713, 2012

R. González-Ramos, J Rocco, C Rojas, H Sovino, A Pock, P Kohen, C Alavaro-Díaz, L Devoto. Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patients. Fertil Steril 97: 645-651, 2012

L. Devoto, A Palomino, P Céspedes, P Kohen. Neuroendocrinology and ovarian aging. Gynecol Endocrinol 1: 14-17, 2012

C. Hetz. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13: 89-102, 2012

A. Zuleta, R Vidal, D Armentano, G Parsons, C Hetz. AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease. Biochem Bioph Res Co 420: 558-563, 2012

C. D. San Martín, T Adasme, C Hidalgo, A C. Paula-Lima. The antioxidant N-acetylcysteine prevents the mitochondrial fragmentation induced by soluble amyloid-β-peptide oligomers.. Neurodegener Dis 10: 34-37, 2012

D. Rojas-Rivera, R Armisén, A Colombo, G Martínez, A Eguiguren, A Díaz, S Kiviluoto, D Rodríguez, M Patron, R Rizzuto, G Bultynck, M L. Concha, J Sierralta, A Stutzin, C Hetz. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ 19: 1013-1026, 2012

N. Juretic, G Jorquera, P Caviedes, E Jaimovich, N Riveros. Electrical stimulation induces calcium-dependent Up-regulation of neuregulin-1β distrophic skeletal muscle cell lines. Cell Physiol Biochem 29: 919-930, 2012

H. Urra, V Torres, R Ortiz, L Lobos, M I. Díaz, N Díaz, S Härtel, L Leyton, A Quest. Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells. PloS One 7: e33085-e33085, 2012

S. Villanueva, C Suazo, D Santapau, F Pérez, M Quiroz, J Carreño, S Illanes, S Lavandero, L Michea, C Irarrazabal. NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney. PLoS One 7: e39665-e39665, 2012

N. Juretic, F Altamirano, D Valladares, E Jaimovich. Muscular Dystrophy. 7: 191-214, 2012

C. D. San Martín, A C. Paula-Lima, C Hidalgo, M T. Nuñez. Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons. Biometals 25: 805-813, 2012

M. J. Barrera, M Sánchez, S Aguilera, C Alliende, V Bahamondes, C Molina, A FG. Quest, U Urzúa, I Castro, S González, H H. Sung, A Albornoz, M Hermoso, C Leyton, M J. González. Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren’s syndrome patients is linked to ectopicmucin secretion. J Autoimmun 39: 83-92, 2012

D. Klionsky, F Abdalla, H Abeliovich, R Abraham, C Hetz, S Lavandero. Guidelines for the use and interpretationof assays for monitoring autophagy. Autophagy 8: 1-100, 2012

R. Vidal, C Hetz. Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease. Autophagy 8: 1-3, 2012

V. Valenzuela, E Collyer, D Armentano, G B. Parsons, F A. Court, C Hetz. Activation of the unfolded protein response enhances motor recovery after spinal cordinjury. Cell Death Dis 3: e272-e272, 2012

M. Torres, L Cartier, J M. Matamala, N Hernández, U Woehlbier, C Hetz. Altered prion protein expression pattern in CSF as a biomarker for creutzfeldt-jakob disease. PLoS One 7: e36159-e36159, 2012

D. Rodríguez, S Zamorano, F Lisbona, D R. Rojas, H Urra, J R. Cubillos, R Armisén, D Henríquez, E H. Cheng, M Letek, T Vaisar, T Irrazabal, C B. González, A. Letai, F M. Pimentel, G Kroemer, C Hetz. BH3-only proteins are part of a regulatory network that control the sustained signallingof the unfolded protein response sensor IRE1α. EMBO J 10: 2322-2335, 2012

R. Vidal, A Figueroa, F Court, P Thielen, C Molina, C Wirth, B Caballero, R Kiffin, J A. Segura, A M. Cuervo, L Glimcher, C Hetz. Targeting the UPR transcription factor XBP1 protects against Huntington’s disease through the regulation of FoxO1 and autophagy. Hum Mol Genet 10: 2245-2262, 2012

S. Zamorano, D R. Rojas, F Lisbona, V Parra, F Court, R Villegas, E Cheng, S Korsmeyer, S Lavandero, C Hetz. A BAX/BAK and Cyclophilin D-IndependentIntrinsic Apoptosis Pathway. PLoS One 7: e37782-e37782, 2012

S. Gupta, D E. Read, A Deepti, K Cawley, A Gupta, D Oommen, T Verfaillie, S Matus, M A. Smith, J L. Mott, P Agostinis, C Hetz, A Smali. Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis. Cell Death Dis 3: e333-e333, 2012

S. Matus, K Castillo, C Hetz. Hormesis: Protecting neurons against cellularstress in Parkinson disease. Autophagy 8: 997-1001, 2012

C. Andreu, U Woehlbier, M Torres, C Hetz. Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications. FEBS Lett 586: 2826-2834, 2012

F. Espinoza, S Kunstmann, A Urzúa, L Michea, E Marusic, A Vukusich. Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients. Rev Med Chil 140: 153-160, 2012

F. Altamirano, J R. López, C Henríquez, T Molinski, P D. Allen, E Jaimovich. Increased resting intracellular calcium modulates NF-κB-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes. J Biol Chem 287: 20876-20887, 2012

G. Martínez, C Hetz. Cell-nonautonomous control of the UPR. EMBO Rep 13: 767-768, 2012

X. Bustamante, C Quiroga, S Lavandero, J G. Reyes, R Moreno. Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes. Apoptosis 6: 539-550, 2012

R. González-Ramos, S Defrere, L Devoto. Nuclear factor–kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology. Fertil Steril 3: 520-528, 2012

C. Alvarez, T Tapia, V Cornejo, W Fernández, A Muñoz, M Camus, M Alvarez, L Devoto, P Carvallo. Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer. Mol Carcinog 7: 1-13, 2012

M. I. Behrens, M Silva, F Salech, D P. Ponce, D Merino, M Sinning, C Xiong, C M. Roe, A FG. Quest. Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer’s patients and skin cancer survivors: increased apoptosis inAlzheimer’s and reduced necrosis in cancer.. J Gerontol A Biol Sci Med Sci 67: 1036-1040, 2012

H. Verdejo, A del Campo, R Troncoso, T Gutierrez, B Toro, C Quiroga, Z Pedrozo, J P. Muñoz, L García, P F. Castro, S Lavandero. Mitochondria myocardial remodeling and cardiovascular disease. Curr Hypertens Rep 14: 532-539, 2012

J. M. Curtis, W S. Hahn, M D. Stone, J J. Inda, D J. Droullard, J P. Kuzmicic, M A. Donoghue, E K. Long, A G. Armien, S Lavandero, E Arriagada, T J. Griffin, D A. Bernlohr. Protein carbonylation and adipocyte mitochondrial function. J Biol Chem 287: 32967-32980, 2012

A. M. Ávalos, F A. Apablaza, M Quiroz, V Toledo, J P. Peña, L Michea, C E. Irarrázabal, F A. Carrión, F E. Figueroa. IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction. Biol Res 45: 193-200, 2012

P. Castro, J L. Winter, H Verdejo, P Orellana, J C. Quintana, D Greig, A Enríquez, L Sepúlveda, R Concepción, P Sepúlveda, V Rossel, M Chiong, L García, S Lavandero. Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure. J Heart Lung Transplant 31: 1096-1101, 2012

M. Nassif, C Hetz. Autophagy impairment: a crossroad between neurodegeneration and tauopathies. BMC Biol 10: 78-82, 2012

H. Urra, C Hetz. The ER in 4D: a novel stress pathway controlling endoplasmic reticulum membrane remodeling. Cell Death Differ 19: 1893-1895, 2012

J. Moya, U Novoa, N Escudero, I Godoy, M Chiong, S Lavandero, J Jalil, M P. Ocaranza. Mayores niveles de ECA y Angiotensina II determinados genéticamente, se asocian a menor actividad del eje ECA2/angiotensina-(1-9) y mayor remodelamiento de la pared aórtica de ratas hipertensas. Rev Chil Cardiol 31: 118-128, 2012

J. Moya, U Novoa, I Godoy, M Chiong, S Lavandero, J Jalil, M P. Ocaranza. Angiotensina – (1-9) disminuye el remodelamiento cardiovascular hipertensivo independiente de los niveles de ECA y de angiotensina II. Rev Chil Cardiol 31: 202-214, 2012