Referencias selectas

Bender, F. Raymond, M., Bron, C. and Quest, A.F.G. “Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity” Cancer Res. 60, 5870-5878 (2000).

Felley-Bosco E., Bender F., Courjault-Gautier F., Bron C., and Quest A.F.G. “Caveolin-1 downregulates inducible nitric oxide synthase (iNOS) via the proteasome pathway in human colon carcinoma cells” Proc. Natl. Acad. Sci. USA, 97, 14334-14339 (2000).

Bender, F., Montoya, M., Monardes, V., Leyton, L., and Quest, A.F.G. “Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1” Biol. Res. 35: 151-167 (2002).

Felley-Bosco, E., Bender, F., Quest, A.F.G. “Caveolin-1-mediated post-transcriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells” Biol. Res. 35: 169-176 (2002).

Hetz, C., Hunn, M., Rojas, P., Torres, V., Leyton, L., and Quest, A.F.G. “Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase” J. Cell Sci. Dec 1;115(Pt 23):4671-4683 (2002). News and Views article in same issue. Citation: A Back-Up Death Plan. Sci. STKE 2002, tw415 (2002).

Quest, A.F.G., Leyton, L., and Párraga, M. “Caveolins, Caveolae and Lipid Rafts in Cellular Transport, Signaling and Disease” Biochemistry and Cell Biology 82:129-144 (2004).

Hetz, C., Torres, V., Quest, A.F.G. “Beyond apoptosis: non-apoptotic cell death in physiology and disease” Biochem. Cell. Biol. 83: 579-588 (2005).

Díaz, L.F., Chiong, M., Quest, A.F.G., Lavandero, S., and Stutzin, A. Meeting Report – Mechanisms of Cell Death: molecular inights and therapeutic perspectives¨ Cell Death and Differentiation 12: 1449-1456 (2005).

Torres, V.A., Tapia, J.C., Parraga, M., Lisboa, P., Montoya, M., Leyton, L., and Quest, A.F.G. “Caveolin-1 Controls Cell Proliferation and Cell Death by Suppressing Expression of the Inhibitor of Apoptosis Protein Survivin”, J. Cell Sci. 119: 1812-1823 (2006).

Tapia, J., Torres, V., Rodríguez, D., Leyton, L., Quest, A.F.G. “Casein kinase 2 (CK2) increases survivin expression via enhanced b-catenin/T cell factor/lymphoid enhancer binding factor-dependent transcription¨, Proc. Natl. Acad. Sci. USA 103: 15079-15084 (2006).

Torres, V, Tapia, J., Lladser, A., Rodriguez, D., Arredondo, C. Leyton, L., Quest, A.F.G., “E-cadherin is required for caveolin-1 mediated down-regulation of the inhibitor of apoptosis protein surviving via reduced β-catenin/Tcf-Lef-dependent transcription” by Mol. Cell Biol . 21: 7708-7717 (2007).

Villena, J., Henríquez, M., Torres, V., Moraga, F., Diaz, J., Arredondo, C., Chiong, M., Olea, C., Stutzin, A., Lavandero, S., Quest, A.F.G., “Ceramide-induced formation of reactive oxygen species and ATP depletion trigger necrosis in lymphoid cells” Free Radical Biol. Med. 44: 1146-1160 (2008).

Henríquez, M., Armisén, R., Stutzin, A., and Quest, A.F.G., “Necrotic cell death, a regulated way to go” (invited review) Current Molecular Medicine, 8: 187-206 (2008).

Quest, A.F.G., Gutiérrez, J. and Torres, V. , “Caveolin-1, an ambiguous partner in cell signaling and cancer”(invited review) J. Cell. Mol. Medicine 12: 1130-1150 (2008).

Rodríguez, D., Tapia, J.C., Fernandez, J.G., Torres, V.A., Munoz, N., Galleguillos, D., Leyton, L., and Quest, A.F.G., “Caveolin-1-mediated suppression of cyclooxygenase-2 via a β-catenin-Tcf/Lef-dependent transcriptional mechanism reduced PGE2 liberation and survivin expression” Mol. Biol. Cell. 20: 2297-2310 (2009).

Valenzuela, M., Perez-Perez, G., Corvalán, A.H., Carrasco, G., Urra, H., Bravo, D., Toledo, H., and Quest A.F.G.. “Helicobacter Pylori-induced loss of the inhibitor of apoptosis protein survivin is linked to gastritis and death of human gastric cells” J. Inf. Disease 202: 1021-1030 (2010).

Urra, H., Torres, V.A., Ortiz, R., Lobos-Gonzalez, L., Díaz, M.I., Díaz, N., Härtel, S., Leyton, L, Quest, A.F.G. “Caveolin‑1‑enhanced motility and focal adhesion turnover require tyrosine‑14 but not accumulation to the rear in metastatic cancer cells” Plos ONE 7(4): e33085 (2012).

Aguirre, A., Kenji F. Shoji, Juan C. Saez, Mauricio Henríquez and Quest, A.F.G. “FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X7“ J. Cell Physiol. 228: 485-493 (2013)

Lobos-González, L., Aguilar, L., Diaz, J., Diaz, N., Urra, H., Torres, V.A., Silva, V., Fitzpatrick, C., Lladser, A., Hoek,K.S., Leyton, L., and Quest, A.F.G. “E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells” Pigment Cell Melanoma Res 26: 555-570 (2013).

Quest, A.F.G., Lobos-González, L., Nuñez, S., Sanhueza, C., Fernández, J.-G., Aguirre, A., Rodríguez, D., Leyton, L., Torres, V. “The caveolin-1 connection to cell death and survival” (invited review) Curr. Mol. Medicine 13: 266-281 (2013).

Díaz, J., Mendoza, P., Ortiz, R., Díaz, N., Leyton, L., Quest, A.F.G. and Torres, V.A. Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells. J. Cell Sci. 127: 2401-2406 (2014).

Núñez-Wehinger, S., Ortiz, R., Díaz, N., Díaz, J., Lobos-González, L., and Quest, A.F.G. “Caveoin-1 in cell migration and metastasis” (invited review) Curr. Mol. Medicine 14: 255-274 (2014).

Lobos-González, L., Fernández, J.G., Aguilar, L., Fernandez, J.G., Muñoz, N., Hossain, M., Bieneck, S., Silva, V., Burzio, V., Sviderskaya, E.V., Bennett, D.C., Leyton, L., Quest,, A.F.G. “Caveolin-1 is a risk factor for post-surgery metastasis in a preclinical melanoma model” Melanoma Research 24: 108-119 (2014).